What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
United States 趨勢
- 1. Knicks 80.5K posts
- 2. Mariah 31.1K posts
- 3. #MightyNeinSpoilers 1,204 posts
- 4. NBA Cup 64.8K posts
- 5. Spurs 48.8K posts
- 6. Buck Rogers 3,655 posts
- 7. #TAEHYUNGxCELINE 46K posts
- 8. thalia 2,821 posts
- 9. Tyler Kolek 7,631 posts
- 10. Thug 24.1K posts
- 11. Gil Gerard 3,578 posts
- 12. Josh Hart 6,399 posts
- 13. Wemby 27.5K posts
- 14. #NewYorkForever 4,849 posts
- 15. Brunson 25.1K posts
- 16. Mitchell Robinson 5,885 posts
- 17. #LMD7 54K posts
- 18. Thea 14.2K posts
- 19. #MAGMA 1,256 posts
- 20. Robert E Lee 9,235 posts
Something went wrong.
Something went wrong.