What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
United States Tendências
- 1. Kansas 18.6K posts
- 2. Jeff McNeil 2,425 posts
- 3. Missouri 6,202 posts
- 4. Arrowhead 3,958 posts
- 5. Vince Zampella 10.6K posts
- 6. Token "F" N/A
- 7. #Fliffmas 1,726 posts
- 8. Titanfall 1,881 posts
- 9. 60 Minutes 142K posts
- 10. Utah State 1,799 posts
- 11. Jackson County 1,279 posts
- 12. Clark Hunt N/A
- 13. Kittle 2,020 posts
- 14. Greenland 37.4K posts
- 15. Zimbabwe 19.7K posts
- 16. Ravi 10.1K posts
- 17. Bari Weiss 117K posts
- 18. Nolan 77.6K posts
- 19. Provo 1,754 posts
- 20. NXXT 1,486 posts
Something went wrong.
Something went wrong.