Joel Geerling
@geerling_lab
Neurology PGY-18 * Neuroanatomy * Iowa Neuroscience
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🧠 NEW RESEARCH: We discovered that a tiny population of neurons in the brainstem is critical for surviving in a cold environment. Without these neurons, mice can't maintain their body temperature and become hypothermic. ❄️🧵 Published in @iScience_CP #Neuroscience
Earlier this morning, ChatGPT 5 offered to illustrate location and connections of HSD2 neurons in a (hallucinated) Figure 7 from a (confabulated) Geerling et al. 2018 publication. I’m not losing sleep over AI/LLMs taking over anytime soon.
This secondary analysis from TRAILBLAZER-ALZ 2 would have been more useful if the authors had also also shown scatterplots of individual donanedab-treated subjects (rather than lumping them together with placebo-treated and chopping the combination into deciles).…
Celebrating history and therapeutic progress in Cystic Fibrosis research (and Dr. Welsh’s Lasker!) @uiowa @IowaMed
NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9.00…
You can read the accepted manuscript version of this paper a J.Neuro now. @SfNJournals. Really beautiful work from @jennisisaac and @sonia_karkare characterizing the organization of various LS projection populations and their inputs. jneurosci.org/content/early/…
Lateral septum enthusiast? Interested in learning more about how LS projection populations and their inputs are organized. Check out our preprint in which @jennisisaac and sonia karkare map out brain wide inputs to 6 LS projection populations. biorxiv.org/content/10.110…
Just saw our first big amyloid reduction in a patient with Alzheimer’s disease (florbetapir PET repeat after 6 monthly infusions of donanemab). Patient doing well, no side effects. Interesting to see such a dramatic change in the brain, and I hope it makes a difference.
I’m proud to share our systematic review & meta-analysis of plasma p-tau diagnostic accuracy studies :) thelancet.com/journals/laneu… Some highlights:
New paper from the lab with @andrewlutas. Work of the amazing Claire Gao. Important read exploring mechanistic insights as to why semaglutide may work better for some versus others. Building on all the amazing research that has been done over the years. biorxiv.org/content/10.110…
This is a direct immunostaining using the frontal lobe of a patient with Alzheimer. Why is there so little high-resolution microscopy being performed in human tissue? There is so much data we can extract..and in 3D! (Dream Theater sounds appropriate this time) #FluorescenceFriday
Looking at some human brains with neurodegeneration and investigating Tau accumulation🟡inside neurons🟣using super-resolution microscopy (🟢nuclei). All the flying 🟡pieces are from dead neurons, and the 2 below are also condemned to die. We still don't know how to avoid this😞
Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.
$15 million gift to the @washumedicine MSTP from Roy and Diana Vagelos. Amazing. Forever grateful for the opportunity this program gave me, it is wonderful to see it continue to thrive and grow. medicine.washu.edu/news/transform…
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