Alexander Bae
@jalex_bae
EM connectomics @ZettaAI Postdoc @SNUnow; PhD @PrincetonNeuro @EPrinceton @Princeton
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Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 Tweeprint! ⬇️1/8
Need an easier way to visualize and collaborate on large-scale volumetric images? Join our live Q&A 'Extending the Neuroglancer Paradigm: Advancing Collaboration on Large-Scale Imaging Data' 👉 Register here: events.zoom.us/e/view/UtTwLDv… 🗓 Tuesday, July 29th | 12:30pm - 2:00pm ET
An important addition to the Nature paper, beyond what was shown in the 2024 preprint, is 12 rounds of iterative imaging and sectioning of a LICONN volume, achieving 205 microns in axial extent (native scale) with manual tracing of axons: nature.com/articles/s4158…
Nature research paper: Light-microscopy-based connectomic reconstruction of mammalian brain tissue go.nature.com/42MnD5S
the best researchers from Meta, Yale, Stanford, Google DeepMind, and Microsoft laid out all we know about Agents in a 264-page paper [book], here are some of their key findings:
![Hesamation's tweet image. the best researchers from Meta, Yale, Stanford, Google DeepMind, and Microsoft laid out all we know about Agents in a 264-page paper [book],
here are some of their key findings:](https://pbs.twimg.com/media/GnyqIQsWcAAQFUI.jpg)
A starburst, the first cell proofread by a citizen scientist (Krzysztof Kruk) in the alpha launch of @eye_wire 2. next gen citizen science projects in the earliest stage ~ pyr.ai This amacrine cell is an interneuron that can act as a local processing unit.…
As people that know me well can attest, I love a good mystery! 🔍 Fortunately for me, this work had twists both surprising and peculiar. 🧵
New Anthropic research: Tracing the thoughts of a large language model. We built a "microscope" to inspect what happens inside AI models and use it to understand Claude’s (often complex and surprising) internal mechanisms.
Finally out. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…
Belated preprint alert! Ever wondered how mitochondrial structure changes across development? Here, we present comprehensive EM reconstructions of mitochondria in C. elegans neurons and muscles from the L1 larval stage to adulthood, including the alternative dauer stage. 1/n
A cell with 3 nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #CellBiology
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
After today's @NobelPrize news conference, @PrincetonNeuro professor @SebastianSeung weighed in on John Hopfield's work in answering some of the universe's greatest questions.
Sydney Brenner established C. elegans as a model organism starting in the 1960s, which led to the first connectome in 1986. In Sept 2007, we invited Sydney to deliver the inaugural lecture for our new @Harvard @MIT class on connectomics, and shockingly he accepted!
Memories. With @srinituraga at #SfN 2007, waiting to deliver my Presidential Special Lecture, "The Once and Future Science of Neural Networks." Pinstripe suit with hot pink trim by Moschino and I really needed a haircut.
Hard to overstate how pleased I am that the #flywire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved.
Here it is! A huge milestone in neuroscience – the complete connectome of the fly brain from the FlyWire team (@FlyWireNews). In this special issue, we have 9 research articles. I’ll try to summarize them in a couple threads starting here 🧵
A team of researchers and citizen scientists led by @Princeton neuroscientists @MurthyLab and @SebastianSeung has created the first ever complete map of a centralized adult brain: the fruit fly 🪰🧠 princeton.edu/news/2024/10/0…
Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
A historic milestone for neuroscience! It's been a fantastic journey for the #FlyWire Consortium. This special edition of Nature showcases the power of open science, with nine papers that not only describe the fly connectome, but also make discoveries using it.
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today
The APL neuron is the longest cell in the fly connectome. There are only 2 in the brain. Each one is 20x longer than the fly's whole body and has well over 100,000 synapses. Explore the fantastic APL cell in Codex: codex.flywire.ai/app/cell_detai…
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