Jennifer Erwin
@jerwinlab
Building real brain medicines from gene discovery | Neurogenetics, ASOs, chromatin, stem cells | @aluco_bio | Academic @Flinders | Opinions my own
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development dlvr.it/TMdp9S
Courage is rarely priced in. This is true of markets, public or private, elections, movements, or any organization that seeks to grow. When you see a courageous act, it can take many months for scale to follow and the narrative to catch up. This is because analysts and experts…
🚨 We're hiring! The Erwin Lab at Flinders University is looking for graduate students and postdocs passionate about neurogenetics, epigenetics & therapeutics. Collaborate with biotech & launch a spinout. 📩 [email protected] 🔗 flinders.edu.au/people/jennife…
1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s4159…
🧠 Our new study is out in Nature Communications! DNMT1 regulates the migration of cortical interneurons, with implications for cortical layering and function — and potentially neuropsychiatric conditions. 🔗 doi.org/10.1038/s41467… Huge thanks to the amazing team/collaborators!
Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue a Postdoc, MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
#PeeWeeAsHimself is this year's highest-rated TV show. editorial.rottentomatoes.com/guide/best-new…
LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis | Science Advances science.org/doi/10.1126/sc…
Join us next Tuesday from 12:00-1:00 at UMB for another Baltimore Brain Series seminar! Awardees Dr. Bradley Keegan from NIDA and Bailey Spiegelberg from UMB will present their exciting work. Zoom link provided upon request! @UMMedNeuro
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s4158…. 1/12
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis…
📢 CUT&Tag version 3 Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript: biorxiv.org/content/10.110…
A great resource: tandem repeat database in @AllofUsResearch with the expert input of @PacBio @MikeEberle @egor_dolzhenko search.app/zkzCsN5Yx7Frwj…
Check out our narrative review published in the new npj_Women's Heath "The biomechanics of the vagina: a complete review of incomplete data" written with the ultimate expert on vaginal biomechanics @devita_vt @UCSD_ObGyn @Nature_NPJ "...By strengthening collaborations among…
1/ 🧵 So excited to finally share our preprint! Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation (SV) on gene expression and DNA methylation- A new genomic resource for brain research! 🧠✨biorxiv.org/content/10.110…
Delighted to see the completed Special Issue of Current Opinion in Genetics and Development on "Genome Architecture and Expression” It was a pleasure putting this together with Maya Capelson. Thanks to all the authors that contributed articles sciencedirect.com/special-issue/…
Topic collection on Brain Cancer – Exploring Genetic and Epigenetic Mechanisms - in Neurogenetics - submissions are welcome, check here for further details: link.springer.com/collections/ge…
Excited to share my lastPhD publication! We discovered non-inherited mutational patterns in schizophrenia occurring before birth. Huge collaborative effort w/ @seplyarskiy @jones_attila science.org/doi/10.1126/sc…
Glad to share the peer-reviewed version of the @mgheffel manuscript now in @Nature. In collaboration with @lab_paredes , we studied the chromatin conformation and DNA methylation changes during human hippocampus and frontal cortex development. nature.com/articles/s4158…
📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.110… 👇Key findings:
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