Xin Lai
@laixinking
A Systems Biologist with passion for research, photograph, and cook.
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New publication at #Bioinformatics of @OxfordJournals. HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor subtypes #CancerResearch #MachineLearning #AIinMedicine #PrecisionOncology academic.oup.com/bioinformatics…
The latest research from Guo's lab at @theNCI shows that one hotspot mutation in #DICER1's RNase IIIb can lead to loss and gain of function 5p-miRNA and the gain of function of 3p-miRNA. rdcu.be/eUxiq
See our new preprint, where we used a network biology method to identify novel therapeutic targets for uveal #melanoma. #networkmedicine #bioinformatics #cancer
A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma biorxiv.org/content/10.110… #biorxiv_cancer
Seedless binding in #miRNAs can also lead to gene repression as shown with miR-155 and miR-124, though this unconventional binding accounts ~1% of miRNA binding. See Bartel lab's new paper for details. Functional microRNA targeting without seed pairing academic.oup.com/nar/article/53…
New preprint on IDH-mutant #astrocytomas: We analyzed rare patient samples showing grade 2-3→4 progression post-therapy. Key findings: #ncRNAs drive astrocyte dedifferentiation; tumor suppressor #miRNA let-7b-3p shows recurrent deletions; #lncRNA NEAT1 regulates ECM organization
Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas biorxiv.org/content/10.110… #biorxiv_cancer
Just published!🦠 Repurposed #clindamycin suppresses #pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 Open access🔓 jeccr.biomedcentral.com/articles/10.11… #DrugRepurposing #TumorAssociatedMacrophages #Immunotherapy #UvealMelanoma
We review a complex #microRNA network that cross-talks with SOX10 and MITF to regulate #tumor plasticity. Network analysis shows miRNA-mediated circuits control signaling pathways - driving phenotype switching, stemness & therapy resistance in #melanoma. doi.org/10.1002/ijc.35…
Registration is NOW OPEN for the 2nd China-Germany-Finland Life Sciences Forum at Tampere University! Join us during our centennial year for cutting-edge bioinformatics & medical informatics in biomedicine. FREE registration! #LifeSciences #Tampere100 events.tuni.fi/cgf-lsf2025/
events.tuni.fi
The China-Germany-Finland Life Sciences Forum 2025 | Tampere Universities
The China-Germany-Finland Life Sciences Forum 2025 | Tampere Universities
📢 Our SI in @Nature_NPJ Systems Biology & Applications is a wrap! 54 submissions, 13 published, 10 in progress! Explore latest #systemsbiology papers and its applications in basic and #translational #research. Many thx to @NetPharMed and @mkjolly15. nature.com/collections/ch…
PLOS Comput. Biol.: ENQUIRE automatically reconstructs, expands, and drives enrichment analysis of gene and Mesh co-occurrence networks from context-specific biomedical literature journals.plos.org/ploscompbiol/a…
United States Xu hướng
- 1. Martinelli 49,2 B posts
- 2. Jonathan Ross 46,7 B posts
- 3. Arsenal 357 B posts
- 4. Liverpool 196 B posts
- 5. JD Vance 243 B posts
- 6. Renee 1,29 Mn posts
- 7. #ARSLIV 31,8 B posts
- 8. Bradley 30,8 B posts
- 9. Gyokeres 28,4 B posts
- 10. 17 Republicans 2.590 posts
- 11. Frimpong 10,6 B posts
- 12. Charlie Kirk 200 B posts
- 13. McDaniel 42,9 B posts
- 14. Fetty Wap 2.648 posts
- 15. Arteta 40,7 B posts
- 16. Josh Hawley 18,5 B posts
- 17. Simeone 43,1 B posts
- 18. Will Cain 2.016 posts
- 19. Lviv 7.812 posts
- 20. PTSD 11,7 B posts
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