Matthieu Benoit
@matthieuBenoit1
Research assistant professor at Albert Einstein College of Medicine. Biophysical studies on molecular motors.
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nature.com/articles/s4146… Since preprint, the #CryoEM datasets were further processed with #Relion to separate kinesin dimers or coexisting conformations on microtubules. 3 of 20 structures (2.7-3.9 Å) below. @SosaLab4 @SEMC_NYSBC #kinesins #microtubules #biophysics #cellbiology
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities came out! 7 #CryoEM structures @SosaLab4. Data collected @SEMC_NYSBC. Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter. nature.com/articles/s4146…
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities 7 #CryoEM structures @SosaLab4 Data collected @SEMC_NYSBC Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter #microtubule dlvr.it/SKrQYT
1/ Excited to share our work on how kinesin binding protein (KIFBP) regulates kinesin! TL;DR: KIFBP remodels the kinesin motor to inhibit microtubule-binding
We are very excited to share our latest work, the high-resolution cryo-EM structure of the ex vivo cortical #microtubules from human parasite #Toxoplasma gondii. This work is in collaboration with David Sibley lab and @alanbrownhms lab. nature.com/articles/s4146…
Fascinating microtubule structures solved by sub-tomogram averaging using EMAN (@sludtke and Muyuan Chen), imaging in @chiulab, segmentation with Segger! Identified tubulin proteins in different arrangements along with other components biorxiv.org/content/10.110…
Another wonderful collaboration with @alanbrownhms and @DutcherLab. Here we put complementary data together to build the complete structure of two distinct radial spokes on doublet microtubule. It was also a great experience to coordinate with the Vale lab for paper submission.
It always amazes me the things that can bind microtubules - our structures of radial spokes bound to ciliary doublet microtubules nature.com/articles/s4159…
18 new #cryoEM structures of the kinesin molecular motor KIF14 reveal its translocation mechanism @SosaLab4 biorxiv.org/cgi/content/sh… Collaboration with Kwok lab. Data collected at @SEMC_NYSBC #EinsteinMed #MTmotors #kinesins #microtubules #biophysics @cryoEM_Papers #cellbiology
First paper from my lab after entering a new field. Great collaboration with @alanbrownhms and @DutcherLab! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎 cell.com/cell/fulltext/…
cell.com
Structure of the Decorated Ciliary Doublet Microtubule
Visualizing axonemal microtubules and the proteins that decorate them, on the outside and inside, points to how the underlying periodic architecture supports cilia function.
Here is what molecular motors, kinesins in this example, actually do to microtubules as they walk on them. 😵 Want to know how microtubules can survive in real life ? Have a look at our recent investigation: biorxiv.org/content/early/… @SamReckPeterson @christlet @Lblanchoin
Pre-print on our latest #PRC2 work, spearheaded by @vignesh_k757 and supported by many collaborators: Curtis Beck, @poepsel_lab, @malamenteau, Jennifer Kosmatka, Dan Toso at the #BACEM facility, and Marco Faini in the Aebersold Lab in Zurich. #cryoEM
JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications biorxiv.org/cgi/content/sh… #bioRxiv
Pre-print on a novel bacterial nanocompartment by @Nichols_NTA (@SavageCatsOnly lab) and our very own @bjlafrance features a beautiful 2.2 Angstrom-resolution #cryoEM structure of the nanocompartment shell. Check it out! biorxiv.org/content/10.110…
Inspiring papers from the Scheres and Stark labs showing the amazing potential of cryo-EM. At 1.2 A resolution, even densities for hydrogen atoms are visible! Congrats to @SjorsScheres, @RaduAricescu and Holger Stark. #journalclub doi.org/10.1101/2020.0… doi.org/10.1101/2020.0…
Sosa lab @EinsteinMed provides structural insights into kinesin-13 mediated microtubule depolymerisation. go.nature.com/2HQuXoi
Leginon's Extended Image Shift Mode Increases the throughput for Single Particle Data Collection cell.com/biophysj/fullt…
This Saturday (28 April), the #LHC operators successfully injected 1200 bunches of protons into the machine and collided them, formally marking the start of the LHC’s 2018 physics season: cern.ch/go/TXD9 @ALICEexperiment, @ATLASexperiment, @CMSexperiment, @LHCbExperiment
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