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2x Preprint drop!!! Mitochondrial pearling has arrived! “The Biophysical Mechanism of Mitochondrial Pearling”. “Pearling Drives Mitochondrial DNA Nucleoid Distribution” 1/10 biorxiv.org/content/10.110… biorxiv.org/content/10.110…
Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub. This is the first large scale scientific…
In the Allostatic Triage Model of Psychopathology (ATP Model), we propose a novel concept: Allostatic Triage: the stress-induced redistribution of energy from CNS networks optimizing long-term outcomes to those supporting short-term survival.
A cell gets beautifully electrifying when squeezed by surrounding crowds nature.com/articles/s4158…
Zebrafish embryo tail, post amputation, showing cell migration to the wound, cell divisions, and vasculature extension toward the cut. Plasma membranes (green), nuclei (red), and erythrocytes (purple) as seen by adaptive optical lattice light sheet on MOSAIC.
Calcium imaging throughout entire fish bodies (including liver, pancreas, and kidneys😋) biorxiv.org/content/10.110…
Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.
🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods! 📦 Ultrack — robust, scalable nD cell tracking 🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration Let’s dive in! 👇 (LINKS BELOW)
Signals of energetic stress including GDF15 and others reach the brain to influence the aging process Superb journalistic writing by @DianaMKwon With contributions by @Dr_Epel @BartolomucciLab @sturm_gav and Anthony Zannas nature.com/articles/d4158…
New paper on mitochondrial distribution across the human body If you have more mitochondria than the average person in your heart, does that mean you also have more than average in your brain, muscles, kidneys, etc? We investigated inter-organ correlations in mitochondria 🧵
Can we feel our mitochondria? We feel pain (nociception), internal sensations (interoception), and even our immune system (immunoception) How does the brain monitor our energy status? In this preprint, we propose that the brain feels the balance of energy demand (burn rate)…
Today, in collaboration w/ colleagues at the Institute of Science and Technology Austria (ISTA), we report the first-ever method for using light microscopy to comprehensively map all the neurons & their connections in a block of mouse brain tissue. More →goo.gle/4maUNUs
Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data! @ecarkfeld @ZacharyWang379 @hhako2 📄: biorxiv.org/content/10.110… 💻: github.com/schoeneberglab… #simulation #latticelightsheet #llsm #microscopy #cellbiology #mitochondria #microtubules
Nellie's image analysis capabilities are vast. I put a video of yeast mitochondria through Nellie and generated a 'live-cell MitoGraph' - a topological graph capturing mitochondrial network's fission and fusion events over time.
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
Nellie is out in Nature Methods! Analyzing live-cell bioimages is really hard. Nellie not only makes this analysis accessible but also brings out the full beauty of your data. Give it a try! (Nellie tracking mitochondria in Blender below).
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of MitotypeExplorer.org Feedback welcome!
All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types) In the end, we are made of dozens of different specialized mitotypes New preprint where…
All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types) In the end, we are made of dozens of different specialized mitotypes New preprint where…
Wow! We knew that mitochondrial DNA were evenly distributed along the inside membrane but didn't know how. This explains it!
The transient nature of pearling makes it hard to detect - in normal cells you might need to sit and watch one spot for a long time and then, if you blink, you'll miss it
All too often, when colleagues suddenly find themselves converging on the same question, it quickly becomes like a knife fight in a telephone booth. Life's too short for that shit, and it's bad for business. Mitomania has exemplified the right way to collaborate!
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