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Nine out of ten people might tell you you're crazy. The tenth might see what you see. This week on the Lightcone, @garrytan, @harjtaggar, @snowmaker, and @sdianahu discuss contrarian bets — the ideas that look impossible until they work. From Uber and Coinbase to DoorDash and…
Super excited that @agentmail is hosting a spooky Halloween themed Hackathon, brought to you by @Replit, @browser_use, @livekit, @convex_dev and @hyperspell at the YC office starting at 6pm on Oct 31 and running for 24 hours!

My journey to @ycombinator started 18 years ago on a trip back from Antarctica. It was Christmas 2006. I’d quit my job and was backpacking through South America, trying to figure out what to do next. Then a friend sent me a link that changed everything…

YC is the YC for hard tech
Congrats to @albacoreinc on their $6.5M seed! Albacore is building underwater drones for the military. Their first product, Ghostfin, is an 8ft modular autonomous submarine designed to patrol undetected for 1,000+ nautical miles & support special ops. tectonicdefense.com/exclusive-yc-b…
One critical point made by Karpathy on the Dwarkesh podcast was about the difference between AI coding agents and the rest of knowledge work. It’s clear that AI agents in coding have taken off extremely quickly. There are many reasons for this, including the fact that a…
Super excited for RL IRL this Saturday at @ycombinator, we're at 500+ registrations! We (@Osmosis_AI) are co-hosting a session with @greptileai on designing RL-ready products - Other sessions in thread 👇

DeepSeek AI dropped a new open-source OCR model today 👀 At @pulse__ai, we tested it on financial docs, handwritten forms, and complex tables. The results showed the same issues plaguing LLM-driven OCR: - Unstable outputs - Hallucinated text - Broken table structures Reality…

Spoke to dozens of GTM leaders at large enterprises. All are frustrated by the same thing: their data is everywhere, but insights are nowhere. At Activeloop today, we are unlocking AI Data Analysis form data silos towards Vibing intelligence.
.@UseCommonPaper just launched Gerri on @ycombinator's Launch YC! Gerri - The AI Agent for Contract Redlines. Check them out: ycombinator.com/launches/OeZ-g…
Big news: Play Health is part of @ycombinator! When we started building Play Health, it came from a simple belief: women need better care as they navigate perimenopause. Every woman will go through it, but too many are left without answers. With YC’s investment and support,…

Congrats to @albacoreinc on their $6.5M seed! Albacore is building underwater drones for the military. Their first product, Ghostfin, is an 8ft modular autonomous submarine designed to patrol undetected for 1,000+ nautical miles & support special ops. tectonicdefense.com/exclusive-yc-b…
The @AnthrogenBio team (@ycombinator S24) just launched Odyssey — a 102B-parameter protein language model and one of the most impressive examples I've seen of what tiny, focused teams can achieve in AI × biology. Anthrogen is a team of six, and they just raised seed funding…
Uplane (@uplane_com) is building software to replace marketing agencies. Their AI generates ads with matching landing pages and steers them across Meta, Google, TikTok, and others. ycombinator.com/launches/Odk-u… Congrats on the launch, @juliuskoerfgen, @Marvin_A_M & @vollmer_lukas!
I'm super bullish on AI reshaping SaaS. We acquired 4 companies and re-orged product development twice this year to do it properly. Most SaaS domains can map to AI, it's just a hard product problem to get right. Specifically, the user interface problem is hard. Most SaaS…
One of Replit's operating principles. Wrote this 5 years ago, and it's surprising how, despite so many things having changed, the values stay the same.

1/ A decade ago, we started a scrappy startup in my dorm room in Waterloo We were so low on cash that we had to ask PG to help us pay for our 1st month’s rent during YC. 3 months later, we were in Bloomberg Now I’m back in @ycombinator a 2nd time with @AtlasGridAI (F25)



The YC community is better than I ever could’ve imagined. People love to shit on YC and act like we’re all like the loudest among us online, but thats not representative of the group. The willingness to help each other and the immediate connection when you meet another YC…
Introducing Odyssey—the largest and most performant protein language model ever created. Odyssey enables scientists and researchers to generate and edit proteins, the workhorses of all life on this planet, towards specific functional ends—scaled to over 102 billion parameters.…
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