#bioorthogonal search results
Dual-Locked Enzyme-Activatable Bioorthogonal Fluorescence Turn-On Imaging of Senescent Cancer Cells | Journal of the American Chemical Society @NTU #Enzyme #Activatable #Bioorthogonal #Fluorescence #Imaging #Senescence #Cancer #Cells pubs.acs.org/doi/10.1021/ja…
Ligand-Directed Photocatalysts and Far-Red Light Enable Catalytic Bioorthogonal Uncaging inside Live Cells @UDelaware #Photocatalysis #FarRedLight #Bioorthogonal #Uncaging #LiveCells pubs.acs.org/doi/10.1021/ja…
Single-Atom Catalysts Mediated Bioorthogonal Modulation of N6-Methyladenosine Methylation for Boosting Cancer Immunotherapy | Journal of the American Chemical Society @CHNSci #SingleAtom #Bioorthogonal #Methyladenosine #Methylation #Immunotherapy #Cancer pubs.acs.org/doi/10.1021/ja…
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells @RockefellerUniv @pfizer_news #Bioorthogonal #Tethering #DrugFragment #Affinity #GProtein #CoupledReceptors #LiveCells pubs.acs.org/doi/10.1021/ja…
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis | Journal of the American Chemical Society #Bioorthogonal #Deep #Red #Photoreddox #Catalysis #Pyroptosis pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis
The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnolog...
Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation | Journal of the American Chemical Society @uarizona @UAZBIO5 @UAZCancer #Bioorthogonal #PROTAC #Prodrug #Activation pubs.acs.org/doi/10.1021/ja…
Site-Specific Bioorthogonal Activation of DNAzymes for On-Demand Gene Therapy | Journal of the American Chemical Society @CHNSci #Bioorthogonal #DNA #DNAzymes #Gene #Therapy pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Site-Specific Bioorthogonal Activation of DNAzymes for On-Demand Gene Therapy
RNA-cleaving DNAzymes hold great promise as gene silencers, and spatiotemporal control of their activity through site-specific reactions is crucial but challenging for on-demand therapy. We herein...
Bioorthogonal Labeling & Enrichment of Histone Monoaminylation Reveal Accumulation & Regulatory Function in Cancer Cell Chromatin | JACS @OhioStateMed @OhioState @OSUCCC_James #Bioorthogonal #Histone #Regulatory #Cancer #Chromatin pubs.acs.org/doi/10.1021/ja…
Enzyme-Mediated Bioorthogonal Catalytic Cascade for Metabolism Intervention & Enhanced Ferroptosis on Neuroblastoma | Journal of the American Chemical Society @CHNSci @JiaoTongUni #Enzyme #Bioorthogonal #Cascade #Metabolism #Ferroptosis #Neuroblastoma pubs.acs.org/doi/10.1021/ja…
Ultrafast Bioorthogonal Spin-Labeling & Distance Measurements in Mammalian Cells with Genetically Encoded Tetrazine AminoAcids JACS @UW @StollPatrol @OregonStateBB @OSUScience #Ultrafast #Bioorthogonal #SpinLabelling #Cells #Encoded #Tetrazine #AminoAcids pubs.acs.org/doi/10.1021/ja…
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy | Journal of the American Chemical Society @genentech #Bioorthogonal #Switching #Antibody #Imaging #Therapy #SPECT pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload:...
Antibody-drug conjugates (ADCs) for the treatment of cancer aim to achieve selective delivery of a cytotoxic payload to tumor cells while sparing normal tissue. In vivo, multiple tumor-dependent and...
Introducing Azomethine Imines to Chemical Biology: Bioorthogonal Reaction with Isonitriles | JACS @ETH_DCHAB @ETH_en @ETH @athanasiomarkos @klanglab @snsf_ch #Azomethine #Imines #Bioorthogonal #Isonitriles #ChemicalBiology #Imaging #LivingCells pubs.acs.org/doi/10.1021/ja…
A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V | Journal of the American Chemical Society @DrGlycoBen @TheCrick @impchemistry #Bioorthogonal #Acetylglucosaminetransferase #Tools #Chemoenzymatic pubs.acs.org/doi/10.1021/ja…
Modular Bioorthogonal Lipid Nanoparticle Modification Platforms for Cardiac Homing | Journal of the American Chemical Society @BristolUni @BrisSynBio @perrimangroup #Bioorthogonal #Lipid #Nanoparticle #Cardiac #Homing pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Modular Bioorthogonal Lipid Nanoparticle Modification Platforms for Cardiac Homing
Lipid nanoparticles (LNPs) are becoming widely adopted as vectors for the delivery of therapeutic payloads but generally lack intrinsic tissue-homing properties. These extracellular vesicle (EV)...
Bioorthogonal Quinone Methide Decaging Enables Live-Cell Quantification of Tumor-Specific Immune Interactions | Journal of the American Chemical Society #Bioorthogonal #QuinoneMethide #Decaging #Tumorspecific #Immune pubs.acs.org/doi/10.1021/ja…
Congrats Nici and Dennis @Click_Chemist 🙃 #bioorthogonal #distortion_rules ;)
Substituent effects in bioorthogonal Diels-Alder reactions of 1,2,4,5-tetrazines (Svatunek et al. @Click_Chemist @MikulaLab @tuvienna) #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…
Tellurophenes! The relentless march of #bioorthogonal chemistry continues: pubs.acs.org/doi/10.1021/ja…
📢 Medicinal Chemistry Postdoc #chempostdoc in New Zealand @otago university. There is still 1 week to apply for a postdoc position in our team developing new #bioorthogonal prodrug strategies. RTs appreciated! otago.taleo.net/careersection/…
Exciting opportunity to join our team as a Postdoc working on Bioorthogonal Prodrug Activation Strategies. This is a 2-year post in Ōtepoti Dunedin on the South Island of New Zealand. otago.taleo.net/careersection/…
Bioorthogonal targeted cell membrane vesicles/cell-sheet composites reduce postoperative tumor recurrence and scar formation of melanoma. | Hongbo Chen @sysu_1924 | [50 days' free access] #CellSheet #MembraneVesicle #bioorthogonal authors.elsevier.com/a/1jJxdcI2-5x0U
![JCRnEDITORS's tweet image. Bioorthogonal targeted cell membrane vesicles/cell-sheet composites reduce postoperative tumor recurrence and scar formation of melanoma.
| Hongbo Chen @sysu_1924 |
[50 days' free access]
#CellSheet #MembraneVesicle #bioorthogonal
authors.elsevier.com/a/1jJxdcI2-5x0U](https://pbs.twimg.com/media/GSCmFBhakAAuAjG.jpg)
Dual-Receptor Targeted Imaging of Cancer Cells with a Bioorthogonal Iridium(III)-Based Probe | Inorganic Chemistry pubs.acs.org/doi/10.1021/ac… Wang, Leung, Wang, and co-workers @InorgChem #iridium #dual_receptor #bioorthogonal #CAIX
"A Smart Ru-Locked #Chemiluminescence Probe via #Bioorthogonal Activation for Highly Selective, Real-Time and Noninvasive In Vivo #Imaging of Thiol Dysregulation" by Xiaofang Hou, Sicen Wang et al. #Ruthenium @WileyBiomedical Check👉doi.org/10.1002/agt2.7…
🔥 Love bioorthogonal chemistry? So do we! 🔬 But multi-labeling reactions come with challenges… 🚧⚡️ Curious about the hurdles & limitations? Check out the Perspective I wrote with @WeilTanja in @J_A_C_S 📖👀@maxplanckpress @MERLN_UM #Bioorthogonal pubs.acs.org/doi/10.1021/ja…
…and it was all yellow 🎶🙃 Many thanks again to the entire team, this time especially to co-author Barbara for the amazing design 💪 Big THX also to @angew_chem for selecting our cover picture! Stay tuned for the next level of bioorthogonal bond-cleavage 😉#bioorthogonal
#OnTheCover Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Hannes Mikula and co-workers) onlinelibrary.wiley.com/doi/10.1002/an… @MikulaLab @tu_wien • onlinelibrary.wiley.com/doi/10.1002/an…
Explore recent progress in #bioorthogonal reactions in living animals with this #ScienceOfSynthesis review, by Frédéric Taran (@TaranLMC), @FabienThoreau, @karine_porte, and @SebastienPapot @UnivParisSaclay. (Eds: J. Mascareñas/M. Tomás-Gamasa @MetBioCat) brnw.ch/21wPeN7
This is an Early View article from the forthcoming volume “Abiotic Reactions in Live Environments”, edited by Jose Mascareñas and Maria Tomás-Gamasa @MetBioCat. Look out for more exciting #ScienceOfSynthesis articles on topics in #bioorthogonal chemistry coming soon!
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis | Journal of the American Chemical Society #Bioorthogonal #Deep #Red #Photoreddox #Catalysis #Pyroptosis pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis
The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnolog...
#FeaturedProtocol this week: #Bioorthogonal tuning of matrix properties during #3Dcellculture to induce morphological and phenotypic changes bit.ly/3YGBmId @JiaResearchLab
doi.org/10.1002/anie.2… To continue the story of hydroxyaryl-tetrazines: sulfonation significantly accelerates release and enables further modification! Shout-out to our collaborators @IOCBPrague Milan Vrabel & team! Many THX & congrats again 🥳 @Patrick__Keppel #bioorthogonal
YELLOW Tetrazines finally published 🙃🟨✂️ Congrats and big THX to the entire team, especially @pg12_wilko, Walter Kuba & @Patrick__Keppel 💪 We keep pushing bioorthogonal bond-cleavage to the next level 📈 More to come soon 😉 Stay tuned! #click-to-release #bioorthogonal
Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Hannes Mikula and co-workers) @MikulaLab @tu_wien #openaccess onlinelibrary.wiley.com/doi/10.1002/an…
Hmmm but does this mean that azides cannot be considered #bioorthogonal ?
[2024 Choh Hao Li Memorial Lecture] is coming in TWO days! This lecture series will cover cutting-edge technologies in #glycobiology, including #bioorthogonal chemistry, GlycoSHIELD, and more! 👉TIME: Oct.2 15:00-17:15 👉VENUE: International Conference Hall, Academia Sinica
#research #bioorthogonal #clickchemistry Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells (Vrábel) - @angew_chem: doi.org/10.1002/anie.2… @IOCBPrague @CzechAcademy @tu_wien
Interesting talk from Guillaume (aka @ClavGuillaume1) from @ChemBioNAC today @Chemistry_QMUL Thanks to @CNRSchimie for providing this opportunity to Guillaume with a travel grant #oligonucleotides, #sulfoclick, #bioorthogonal, #DNA, #RNA
A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V | Journal of the American Chemical Society @DrGlycoBen @TheCrick @impchemistry #Bioorthogonal #Acetylglucosaminetransferase #Tools #Chemoenzymatic pubs.acs.org/doi/10.1021/ja…
[2024 Choh Hao Li Memorial Lecture] is coming! Dr. Bertozzi, one of our guest speakers this year, founded the field of #bioorthogonal chemistry, for which she shared the 2022 #NobelPrize in Chemistry. Her group also invented #glycoproteomics technologies for biomarker discovery.
Tellurophenes! The relentless march of #bioorthogonal chemistry continues: pubs.acs.org/doi/10.1021/ja…
"Lipids on the move": Thank you to @nchembio for highlighting our latest #lipidtime work using #bioorthogonal chemistry to image rapid, inter-organelle lipid transport, by Lin Luan, Dongjun Liang, and @ReikaTei in #ACSChemBio! nature.com/articles/s4158… pubs.acs.org/doi/full/10.10…
pubs.acs.org
Imaging Interorganelle Phospholipid Transport by Extended Synaptotagmins Using Bioorthogonally...
The proper distribution of lipids within organelle membranes requires rapid interorganelle lipid transport, much of which occurs at membrane contact sites and is mediated by lipid transfer proteins...
Controlled bioorthogonal activation of Bromodomain-containing protein 4 degrader by co-delivery of PROTAC and Pd-catalyst for tumor-specific therapy. | Yuan Ping @ZJU_China | #prodrug #PROTAC #bioorthogonal #photothermal doi.org/10.1016/j.jcon…
Had the pleasure of hosting today’s @MoffittNews Cancer Biology Evolution seminar speaker @jenn_prescher who shared her lab’s exciting work on #bioorthogonal approaches to develop novel imaging tools and methodologies! #bioluminescence #phasor_microscopy
From the current issue's covers: #Bioorthogonal #Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications by Kosaka, Yamaguchi, Okamoto & coworkers Learn more: go.acs.org/2rO
Congratulations to Lin @1in_1uan for passing her A exam! Read about some of her recent work in our preprint on #bioorthogonal tools for imaging inter-organelle lipid transport! #lipidtime biorxiv.org/content/10.110…
Our work "Origin of Increased Reactivity in Rhenium-Mediated Cycloadditions of Tetrazines" is now available on @ChemRxiv. doi.org/10.33774/chemr… @houk100 @AnetaTurlik @uclachem @tuvienna #compchem #bioorthogonal
Developments in metal-#catalyzed #bioorthogonal reactions for #biomolecule tagging are reviewed (@junseoklee @KistPublic) doi.wiley.com/10.1002/cbic.2…
#Neurodegenerative protein aggregates can be visualized & quantified in live cells by #bioorthogonal stimulated Raman scattering microscopy. New #FirstRxns by De-en Sun & Xing Chen @PKU1898 bit.ly/2WL8uQC on the research by @Lu_Wei8 and Team bit.ly/3dux0LP
Here's another great @ChemSocRev cover to see everyone into the weekend: "Click and release: #bioorthogonal approaches to “on-demand” activation of #prodrugs" by Bowen Ke & Binghe Wang et al. @GeorgiaStateU #drugdelivery To find out more, go to: ow.ly/4gxL30nSVc0
College of Chemistry Catalyst magazine out now online. Read about @NobelPrize winner @CarolynBertozzi and her time @UCBerkeley and #bioorthogonal chemistry discoveries. catalyst.berkeley.edu/2023/06/20/car…
#Bioorthogonal metalloporphyrin-catalyzed selective methionine alkylation in the lanthipeptide #nisin (Roelfes @univgroningen) doi.wiley.com/10.1002/cbic.2…
Explore recent progress in #bioorthogonal reactions in living animals with this #ScienceOfSynthesis review, by Frédéric Taran (@TaranLMC), @FabienThoreau, @karine_porte, and @SebastienPapot @UnivParisSaclay. (Eds: J. Mascareñas/M. Tomás-Gamasa @MetBioCat) brnw.ch/21wPeN7
Ken Houk @houk1000 kicked off the #Shenzhen #FEP symposium with a super QM talk on #bioorthogonal reactions and #DirectedEvolution @CarolynBertozzi @francesarnold
Always a thrill to give the #bioorthogonal chemistry lecture today in Principles of Chemical Biology @CornellChem — for sure a periodic table socks-worthy day! Hopefully one of these years I’ll get to add the Nobel Prize slide to this lecture to join many others in this course 🤩
The final version of our #bioorthogonal #lipidtime method for imaging rapid inter-organelle transport of fluorescent phospholipid analogs is now published — congrats to Lin Luan (@1in_1uan), Dongjun Liang, Dylan Chiu, & @ReikaTei! doi.org/10.1021/acsche…
🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to directly quantify discrete steps in this network, which are mediated by a large group of lipid transfer proteins working at membrane contact sites between different organelles. 1/2 doi.org/10.1101/2023.0…
The #ESMEC click-and-tag crew! 💪 I had the privilege to chair a great session showcasing how functional groups and synthetic methods can be exploited in #bioorthogonal chemistry to navigate problems facing medicine, to discover new drugs and diagnostics. @esmecurbino @DCFSCI
Our new paper in @OrgBiomolChem is out. We report on the kinetics of TCO and aryl azide self-immolative linkers, and have identified a combination with fast click-and-release kinetics #bioorthogonal chemistry. pubs.rsc.org/en/content/art…
Celebrating the #bioorthogonal #clickchemistry #ChemNobel with a special “Yay for click chemistry!” cake with Carolyn’s academic grandchildren @CornellChem @weillinstitute! Congratulations again, @CarolynBertozzi!!
SPAAC: strained cycloalkynes and controlling reactivity in click transformations, by Trevor Harris (@BalabushkaFury) and Igor Alabugin (@IAlabugin) for Science of Synthesis #bioorthogonal @ChemistryFsu fal.cn/3o7ig fal.cn/3o7if
SAVE THE DATE📣 Our new Thieme Web #Cheminar series starts on 22nd February! First topic: Click and #bioorthogonal #chemistry – recent progress, presented by Hannes Mikula and John Moses (Chair:@FlorisRutjes). @MikulaLab @HarborSpring Registration is🔓👉fal.cn/3lJgd
Had the pleasure of hosting today’s @MoffittNews Cancer Biology Evolution seminar speaker @jenn_prescher who shared her lab’s exciting work on #bioorthogonal approaches to develop novel imaging tools and methodologies! #bioluminescence #phasor_microscopy
We can't wait until 22nd February, when the first Thieme Web #Cheminar on #ClickChemistry and #bioorthogonal chemistry (presented by @FlorisRutjes @MikulaLab @HarborSpring) starts💻⚛️👨🏫💬 Be part of it from 3-5 pm (CET) / 9-11 am (EST) and sign up now👉📝fal.cn/3lWeG
🚨New paper! We applied our #bioorthogonal #lipidtime imaging methods with CRISPR screening to discover new regulators of phospholipase D signaling. Thrilled to see this work of Tim Bumpus, Shiying Huang, & @ReikaTei published in @PNASNews: pnas.org/content/118/48…. Thread: 1/7
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