#tnbc search results
$INTS is presenting two posters at @SABCSSanAntonio. PS5-08-16 shares early Ph2 INVINCIBLE 4 #TNBC data showing favorable safety, with #INT2306 patients reporting 50% fewer grade 3+ adverse events vs standard neoadjuvant chemo. PS4-10-15 outlines a potential Ph3 study design
First-line metastatic TNBC has officially changed! The key question is no longer “chemo or not?” It’s which ADC, for which patient, with which toxicity trade-off. Welcome to the ADC-first era in metastatic TNBC. #ASCO #ESMO #TNBC #BreastCancer #ADC #Sacituzumab #DatoDXd
Exploring new strategies in #TNBC with Alexandra Indeglia, PhD who discussed targeting transcriptional drivers of plasticity and resistant cell states in #TripleNegativeBreastCancer at the @df_hcc #BreastAndGynecologicCancerSymposium.
ICYMI 👉Here are recent results from the ASCENT-04 trial published in @NEJM. 👉pubmed.ncbi.nlm.nih.gov/41564397/ The study found that among patients with previously untreated, PD-L1+ advanced #TNBC, sacituzumab govitecan plus pembrolizumab resulted in longer PFS than chemotherapy plus
New 📰Androgen receptor expression and immune characteristics of HER2-low metastatic #TripleNegativeBreastCancer. 👉pubmed.ncbi.nlm.nih.gov/41688468/ @PTarantinoMD @BusemBKurt @RMJesel @nlinmd @EMittendorfMD @SchnittStuart @shomgoel @stolaney1 #TNBC #MBC #BreastCancer
• Gupta et al. (Carboplatin in TNBC, JCO 2025) • EFS missed, OS delivered • Not biology — statistics (events + power + time) • Negative primary ≠ negative drug #TNBC #BreastCancer #ClinicalTrials #Oncology #Stats #MVOnco
PLANeT trial challenges how we dose immunotherapy in early TNBC: Low-dose pembrolizumab (50 mg q6w ×3) + NACT → Meaningful pCR improvement (+13.3%) → Efficacy signal comparable to KEYNOTE-522 → No increase in grade ≥3 toxicity Smarter dosing matters. #TNBC #Immunotherapy
Early signals from the DB-1305 TROP-2 ADC show antitumor activity in heavily pretreated metastatic TNBC, with manageable TRAEs and no treatment-related deaths. @ErikaHamilton9 outlines next steps for combinations. 💡 Read more: hubs.li/Q03VHTRV0 #BreastCancer #TNBC
FDA Grants Priority Review to DATROWAY sBLA for First-Line Treatment of Metastatic Triple-Negative Breast Cancer - For More Information Visit shorturl.at/NaXsY @DaiichiSankyoUS #Breast_Cancer #TNBC
MRD monitoring via ctDNA post-surgery may refine risk stratification in TNBC: MRD-positive patients without pCR face an 87% recurrence risk. 🩸 Learn more: hubs.li/Q03YCT030 #BreastCancerResearch #TNBC #HemeOnc
With strong survival gains already shown in ASCENT, attention is turning to sacituzumab govitecan as a potential frontline option for metastatic TNBC, including patients not eligible for immunotherapy. 🎯 Read more: hubs.li/Q03-55Yh0 #TNBC
Erica Mayer, MD, MPH, (@elmayermd) discusses results of the phase 2 @TheTBCRC 056 trial evaluating neoadjuvant niraparib plus dostarlimab in patients with germline BRCA- or PALB2-mutated #TNBC. #TripleNegativeBreastCancer #BreastCancer healio.com/news/hematolog…
Innovative research from @yalepathology presented #AACR25 uses spatial profiling & machine learning to develop cost effective predictive biomarkers in #TNBC #breastcancer @tznaung @DavidRimm @YaleMBB @AACR @SmilowCancer
Register for the Spring #TNBC Symposium happening in Seville, Spain on April 10th, 2026! The in-person event is hosted by Dr. Luis de la Cruz, Dr. Fernando Henao and Dr. Ana Garrido-Castro 🟪Check out the program and register today! tacticsmd.net/actividad/spri…
Carol MacKenzie, faced #TripleNegativeBreastCancer with limited options – but then a clinical trial offered a new path. Her story shows how #AntibodyDrugConjugates are giving some patients renewed hope and more time. #TNBC #BreastCancer #ADCs @stolaney1 @nlinmd
Supporting #breastfeeding could reduce new diagnoses of #TNBC by up to 15% in Black women and 12% in White women according to a study led by Dr. Lajos Pusztai @YaleBreast. nature.com/articles/s4152… @SmilowCancer @YaleMed @YNHH @Nature_NPJ
ORR 23% with Emi-Le in B7-H4 high #TNBC (29% ≤4 prior lines); median PFS 16 wks vs 6–7 wks in B7-H4 low, OS not reached in select subgroups. Dr. Antonio Giordano (@antgiorda) of @DanaFarber presents Phase 1 data on anti-B7-H4 ADC at #DAVABreast. #BreastCancer
Impressive 79% ORR achieved with dato-DXd + durvalumab in advanced TNBC, highlighting new hope for patients and clinicians. Explore the data: hubs.li/Q046QGN70 #oncology #TNBC
Stay ahead in #TNBC care. Join us for a 6-part series on the latest ADC clinical data, TROP-2 targets, and evolving standards for early-stage and metastatic disease. #BCSM Watch Now: hubs.li/Q0416hD_0
CytoDyn Announces First Patient Dosed in Expanded Access Program for Leronlimab in Triple-Negative Breast Cancer - For More Information Visit checkorphan.org/news/502047/ #CytoDyn #Rare_Diseases #TNBC #Breast_Cancer #Orphan_Drugs #Cancer_research #Cancer_Drugs
Excited to share our @ASCO Educational Book article on updates in management of stage 2-3 #TNBC. In this article, we review: - Current standard of care for stage 2-3 TNBC - Novel investigational therapies and combination strategies, including ADCs, anti-VEGF therapies, dual
♀️🫶 Honored to join the discussion on biology-directed RT for MBC @GBCC_Korea - great exchange on trial design frameworks and upcoming studies incl. AVATAR2 (@TROGfightcancer), Clarity (@NRGonc), and S2511 (@SWOG). Time to push forward a dedicated trial for #TNBC?
The ncRNA-derived peptide 66CTG drives #TNBC growth by stabilizing c-Myc and upregulating Cyclin D1 via FBW7α interaction, revealing a novel #Oncogenic axis and potential #TherapeuticTarget. #BreastCancer #STTT #OpenAccess: doi.org/10.1038/s41392…
$INTS recently shared a Phase 2 INVINCIBLE-4 update for INT230-6 in #TNBC. Preliminary observations showed higher pCR and fewer high-grade AEs vs SOC. Enrollment restart pending. Read more: bit.ly/4lpFI13 #ClinicalTrials
pharmadevicenews.com/why-cytodyn-in… #Oncology #BreastCancer #TNBC #Immunotherapy #AACR2026 #Biotech #ClinicalTrials #CancerResearch #PDL1 #ImmunoOncology
pharmadevicenews.com
Why CytoDyn Inc.’s leronlimab data could reshape TNBC immunotherapy strategies - PharmaDeviceNews
Discover how CytoDyn Inc.’s leronlimab data could reshape TNBC immunotherapy and expand checkpoint treatment potential.
Are you ready to maximize clinical benefit for your patients with #TNBC and HR+, HER2- #BreastCancer? Watch this new PeerView activity for expert, data-driven insight on how TROP2-targeting ADCs are reshaping care! bit.ly/46XelF6 #Oncology #MedEd
Best scientific event of the year for me starting today! #AACR26 ! This year is more special! My work on the contribution of subtypes of neutrophils to systemic inflammatory in #TNBC brought me Scholar-in-Training Award! Visit the related work and contributions of our lab (below)
Integrative proteogenomic profiling enables robust prediction of chemotherapy resistance in #TNBC and identifies actionable biomarkers providing a framework for advancing personalized therapeutic strategies. 🧬@GenomeBiology | bit.ly/4csd2Rc
Triple Negative Breast Cancer: A Breakthrough Treatment bit.ly/4txJybj Read now at PatientWorthy.com #PatientWorthy #TripleNegativeBreastCancer #TNBC
Triple-negative breast cancer (#TNBC) does not have the same receptors as most other types of #breastcancer. David Riseberg, M.D., Chief, Medical Oncology & Hematology at Mercy, appeared in-studio to discuss, on #WBAL-TV11's "The Woman's Doctor". @wbaltv11 wbaltv.com/article/mercy-…
pharmadevicenews.com/how-cellectar-… #CellectarBiosciences #CLR125 #TNBC #BreastCancer #Radiopharmaceuticals #PrecisionOncology #ClinicalTrials #OncologyNews
pharmadevicenews.com
How Cellectar Biosciences, Inc. is positioning CLR 125 for a differentiated TNBC treatment thesis -...
Cellectar Biosciences, Inc. begins CLR 125 Phase 1b in refractory TNBC. Read what this could mean for precision radioconjugate oncology.
Cellectar Biosciences Enrolls First Patient in Phase 1b Trial of CLR 125 for Triple-Negative Breast Cancer, Advancing Targeted Radioconjugate Therapy - For More Information Visit shorturl.at/vS0lp @CellectarBio #TNBC #Breast_Cancer #Orphan_Drugs #Rare_Diseases
🚨 Deadline approaching | Call for Papers 🚨 JCMT Special Topic: Triple-Negative Breast Cancer: From Mechanisms to Translational Frontiers 📅 Deadline: 31 May 2026 👤 Prof. Gary J. Whitman (MDACC) 🔗 Submit: oaecenter.com/login?JournalI… #TNBC #Oncology #CancerResearch #JCMT
🚨 TNBC treatment is being redefined: ADCs take center stage New insights from the 2026 ASCO Educational Book highlight a paradigm shift in metastatic #TNBC —from chemotherapy → to targeted and immune-based strategies 🔍 Key updates: 🔵 PD-L1+ disease • Pembrolizumab + chemo
The guidelines say sacituzumab + pembro is ready for first line PDL1+ stage IV TNBC, based on Ascent 04. Do you think the data actually supports that? Find out what the trial shows: youtube.com/shorts/xwERcbC… #ASCENT04 #TNBC #BreastCancer #Trodelvy
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திமுக கூட்டணிக்கு தமிழக ஆயர் பேரவை ஆதரவு #TNBC | #DMK | #Election2026 | #ElectionWithPT | #TNElection
TODAY IN @Nature 📢 #CancerGrandChallenges team SPECIFICANCER identifies a combination of inhibitors targeting epigenetic and oncogenic pathways, which drive differentiation to enable hijacking of tissue-specific cell death pathways in #TNBC. More 👉 bit.ly/483dO4E
• Gupta et al. (Carboplatin in TNBC, JCO 2025) • EFS missed, OS delivered • Not biology — statistics (events + power + time) • Negative primary ≠ negative drug #TNBC #BreastCancer #ClinicalTrials #Oncology #Stats #MVOnco
New 📰Androgen receptor expression and immune characteristics of HER2-low metastatic #TripleNegativeBreastCancer. 👉pubmed.ncbi.nlm.nih.gov/41688468/ @PTarantinoMD @BusemBKurt @RMJesel @nlinmd @EMittendorfMD @SchnittStuart @shomgoel @stolaney1 #TNBC #MBC #BreastCancer
$INTS is presenting two posters at @SABCSSanAntonio. PS5-08-16 shares early Ph2 INVINCIBLE 4 #TNBC data showing favorable safety, with #INT2306 patients reporting 50% fewer grade 3+ adverse events vs standard neoadjuvant chemo. PS4-10-15 outlines a potential Ph3 study design
Fred Hutch translational researcher Dr. Kevin Cheung just received a $2M Breakthrough Award from the U.S. DoD’s Congressionally Directed Medical Research Programs, or CDMRP, to investigate a newly discovered pathway involving triple negative breast cancer, or #TNBC. 1/5
BT8009 in #TNBC! Dr. Jordi Rodon (@MDAndersonNews) shares Phase I data; ORR 63% in NECTIN4-amplified breast cancer (5/8) vs 14% overall, 57% in NECTIN4-amplified TNBC (4/7) with 100% DCR. Bicycle-based ADC shows biomarker-linked activity. #BreastCancer #DAVABreast
Huge congrats to @batraatulonc & the stellar team at @aiims_newdelhi on publication of the #PLANeT trial (chemo +/- low dose pembro in #TNBC) in @Annals_Oncology. A Herculean effort done at an amazing pace, with key implications that could extend across other areas in #oncology.
Delighted to share that the full paper of PLANeT trial is now available online in @Annals_Oncology We demonstrated that pembrolizumab dose as low as 50 mg every 6 weeks led to an improvement in PCR rates by 13.3%. @hoperugo @montypal @neerajaiims @PTarantinoMD @dradhiparora
A team of researchers has discovered how an RNA promotes the growth of triple-negative breast cancer (#TNBC) by activating two distinct molecular pathways and identified a new combination treatment that suppresses TNBC in culture. @BIDMChealth scim.ag/3ZADrpW
NEWS FROM INDUSTRY: Source Business Wire Update ASCENT-03 The Phase 3 ASCENT-03 trial sees sacituzumab govitecan-hziy improves progression-free survival compared to standard chemotherapy in patients with first-line metastatic triple-negative #BreastCancer (m #TNBC ) who are
Day # 2 of #BreastCancerACTIONMonth - Facts-a-Day from @metavivor Dx stage I tnbc 2011 no lymph node involvement, w. a Stage IV #metastatic #TNBC recurrence 5 yrs later in 2016, w. mets to distant lymph nodes (chest wall & contralateral hilar). Thanks to a proactive Med Onc, a
Day3⃣ #OncoAlertColloquium 🚨 #BreastCancer REGISTER for FREE HERE👉 buff.ly/4aUryQA @hoperugo 🇺🇸 of UCSF Covering Advanced #TNBC : Year in Review REGISTER NOW for a Live chat with Dr. Rugo In 2024, practice-changing data in triple-negative breast cancer (TNBC) supports
Automated discernment of prognostic spatial features of #TNBC specific to cell interactions at the tumor border or metastatic site @NatureCancer @Stanford @MikeAngeloLab @NoahGreenwald @JoleneRanek nature.com/articles/s4301… nature.com/articles/s4301… nature.com/articles/s4301…
PLANeT trial challenges how we dose immunotherapy in early TNBC: Low-dose pembrolizumab (50 mg q6w ×3) + NACT → Meaningful pCR improvement (+13.3%) → Efficacy signal comparable to KEYNOTE-522 → No increase in grade ≥3 toxicity Smarter dosing matters. #TNBC #Immunotherapy
Analyzing #TNBC cells, a team finds the transcription factor Hox-C12 supports metastasis by connecting beta2-ARs to a calcium-cAMP loop and show that HOXC12 expression correlates with worse survival in patients. @MIPS_Australia @Dr_MLHalls @TerranceLamm scim.ag/45nKIgw
திமுக கூட்டணிக்கு தமிழக ஆயர் பேரவை ஆதரவு #TNBC | #DMK | #Election2026 | #ElectionWithPT | #TNElection
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