#assembloid search results
Today we are sharing our most complex #assembloid to date: a 4-part model of the human ascending neural somatosensory pathway generated by functionally integrating stem cell-derived cerebral cortical, thalamic, spinal and sensory #organoids. Check out the @biorxivpreprint and…
This week we welcome the 2025 class of students for our hands-on Stanford @BrOrganogenesis course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to…
This short movie shows human skeletal muscle responses (hSkM) following optogenetic stimulation of cortical #organoids in a three-part cortico-spinal/hindbrain-muscle #assembloid:
The newest 3D brain #assembloid to build from parts & probe human cortico-striatal interactions, and to study disease is out in @NatureBiotech. Check this short summary of the article prepared by our very own @myym_yuki who bravely led this effort in lab! nature.com/articles/s4158…
An insightful spotlight in @NeuroCellPress this week by @Knoblich_lab about our recent work led by @XiaoyuChenxy & @fikribirey combining in vitro #assembloid & #organoid models and in vivo transplantation approaches to translate disease biology into potential therapeutics…
Our three-part, human stem cell-derived cortico-motor #assembloid article is on the cover of Cell @CellPressNews today. Work led by @jimena_andersen @Stanford @StanfordBrain @StanfordBioX @Stanford_ChEMH @cziscience @nyscf @BrOrganogenesis cell.com/cell/fulltext/…
New Resource in the latest issue! #Organoids that resemble the #cerebral cortex or the #hindbrain/spinal cord are assembled with #human skeletal #muscle spheroids to generate 3D cortico-motor assembloids bit.ly/34H4d3I @PascaStanford @Stanford
Immune-Vascular Forebrain #Organoid #Assembloid to model the impacts of APOE genotype (ε2/2 vs 3/3 vs 4/4) on #SARSCOV2 infection Isogenic #hiPSC-derived FOXG1+Nestin+ forebrain neural progenitor➡️ forebrain neuron + astrocyte + oligodendrocyte hiPSC-derived yolk sac➡️…
Philipp Wörsdörfer (@woephi) and colleagues describe a novel neuro-#mesodermal #assembloid model that recapitulates aspects of peripheral nervous system development, such as #NeuralCrest cell induction, and much more! 📖 Full study in @stemcellreports: bit.ly/43LJ6u2
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation 1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid Beautiful vascular network! Can we further differentiate it into A-C-V microcirculatory unit?😁 @marianamvab bioRxiv 2025…
Today we report in @CellCellPress the most advanced #assembloid so far to build the human corticomotor pathway from stem cell-derived parts. This circuit self-assembles & cortical stimulation triggers muscle responses. Led by the amazing @jimena_andersen bit.ly/37qaJ0C
cell.com
Generation of Functional Human 3D Cortico-Motor Assembloids
The assembly of 3D cultures derived from hiPS cells resembling cerebral cortex, hindbrain/spinal cord, and skeletal muscle form neural circuits that can be readily manipulated to model cortical...
Led by Benjamin Sharpe (@BSharpeNotFlat), members of the Underwood lab (@TimTheSurgeon) characterized co-culture tumor-derived #organoids and cancer-associated fibroblasts in matrix-embedded #assembloid models of esophageal adenocarcinoma. 👉 bit.ly/3CMwD09
Learning to make #hPSC-derived Cortical #Organoid & Cortico-Pericyte #Assembloid #Pericyte as a secretory source of LIF ⏫Organized architecture of outer radial glia in Neuronal Rosettes @rluongo90 @BaggioliniA @STARProtocols 2024 sciencedirect.com/science/articl…
#3D '#Assembloid' shows how #SARS-#CoV-2 infects Brain Cells Researchers have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2 into the human brain. See more ... buff.ly/3BgbiHr
After months of prep, the Surgical Innovations Unit at @WestmeadHub has finally started lab work! Super exciting! We r developing a novel #PancreaticCancer #assembloid model to understand #metastasis (#cancer spread). Here is our postdoc @Connordoessci and me at our new lab
Dr. Sergiu Pasca @Sergiu_P_Pasca co-organizer of #cshlbrain discussing revolutionary #organoid #assembloid technologies from #stemcells for #neurologicaldisorders #diseasemodeling
Today's read is one that you cannot miss! This @Nature paper by Drs. @Sergiu_P_Pasca, @XianglingM, @panagiog, and team highlight the power of a #CRISPR-#assembloid platform to systematically map NDD genes onto human development. Congratulations to all the authors! 🥳🎉
There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in @Nature today, we start tackling this question by combining forebrain #assembloids with CRISPR…
Great lecture by @Sergiu_P_Pasca on #assembloid @UCLchildhealth @DBC_ICH time to generate more assembloid from GI systems… watch this space @GiobbeGiovanni
Immune-Vascular Forebrain #Organoid #Assembloid to model the impacts of APOE genotype (ε2/2 vs 3/3 vs 4/4) on #SARSCOV2 infection Isogenic #hiPSC-derived FOXG1+Nestin+ forebrain neural progenitor➡️ forebrain neuron + astrocyte + oligodendrocyte hiPSC-derived yolk sac➡️…
This week we welcome the 2025 class of students for our hands-on Stanford @BrOrganogenesis course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to…
Drs. @GregScherrer25 and @Sergiu_P_Pasca collaborated to establish a human ascending somatosensory #assembloid from #hPSCs that integrates somatosensory, spinal, thalamic, and cortical #organoids to model the spinothalamic pathway. 🧠 @Nature | go.nature.com/3RLmd56
Evolving from organoid to assembloid with enhanced cellular interactions 10.26599/CO.2025.9410010 This review explores the emerging field of #assembloid technology, which integrates multiple #organoids or cell types into self-organizing 3D systems.
Great lecture by @Sergiu_P_Pasca on #assembloid @UCLchildhealth @DBC_ICH time to generate more assembloid from GI systems… watch this space @GiobbeGiovanni
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation 1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid Beautiful vascular network! Can we further differentiate it into A-C-V microcirculatory unit?😁 @marianamvab bioRxiv 2025…
Incredible new work from @KostinaAleksa, @aaguirrecano, & team at @MSUIQ! This functional, highly complex human heart #assembloid could shed new light on cardiac development & congenital heart defects, while also serving as a tool for high-throughput drug screening.
I am pleased to present the latest work from our lab, a human heart-macrophage assembloid model powered by self-organization that incorporates autologous cardiac embryonic macrophages into human pluripotent stem cell-derived heart organoids: biorxiv.org/cgi/content/sh…
Led by Benjamin Sharpe (@BSharpeNotFlat), members of the Underwood lab (@TimTheSurgeon) characterized co-culture tumor-derived #organoids and cancer-associated fibroblasts in matrix-embedded #assembloid models of esophageal adenocarcinoma. 👉 bit.ly/3CMwD09
Combined #assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human #fallopian tube | Science Advances science.org/doi/10.1126/sc…
#Assembloid models of cell-cell interaction to study tissue and disease biology cell.com/cell-stem-cell…
cell.com
Assembloid models of cell-cell interaction to study tissue and disease biology
Complex cell-cell interactions during human organogenesis and disease states have been challenging to study. Here, we review how self-organizing assembloids are emerging as a powerful platform to...
Great #assembloid model to probe the interaction between cortex and thalamus at both cellular & circuit levels, shedding light on atypical crosstalk giving rise to neurodevelopmental disorders. Kudos to @Sergiu_P_Pasca’s team; study led by Ji-il Kim, Yuki Miura and @Minyin_Li 👇
Our newest work is online now in Neuron @NeuroCellPress showing the generation of diencephaluc #organoids, assembly to form cortico-thalamic #assembloids and their application to discover defects following loss of function and gain of function mutations in CACNA1G, which are…
Impressive brain #assembloid work by Yuki Miura, Ji-Il Kim @Sergiu_P_Pasca and colleagues: an in vitro cortico-striatal-thalamic-cortical circuit! 👇
Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in…
Another week another #assembloid system
Biocompatible two-photon polymerization (TPP) #3D-printed meshed vessels facilitate the dimensional breaking growth of #BrainOrganoids and multiregional #assembloids. #OpenAccess: go.acs.org/aWh
Nice #assembloid system
Online Now! Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids dlvr.it/TD3yKs #stemcells
cell.com
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac...
The atrioventricular (AV) canal maintains the electrical conduction between atria and ventricles. Devalla and colleagues generate AV canal cardiomyocytes from hiPSCs using WNT2 and retinoic acid....
Learning to make #hPSC-derived Cortical #Organoid & Cortico-Pericyte #Assembloid #Pericyte as a secretory source of LIF ⏫Organized architecture of outer radial glia in Neuronal Rosettes @rluongo90 @BaggioliniA @STARProtocols 2024 sciencedirect.com/science/articl…
Proteomics of DIPG-cortical assembloids. I hope that this kind of technology enables us to understand the biology of DIPG in more depth and perform drug screening efficiently. #DIPG #assembloid #organoid sciencedirect.com/science/articl…
New Review📖 "Organoids in concert: engineering in vitro models toward enhanced fidelity" by Chunyi Wen et al. @HongKongPolyU @WileyBiomedical #assembloid #biomaterial #microfluidic #organoid Check👉doi.org/10.1002/agt2.4…
An insightful spotlight in @NeuroCellPress this week by @Knoblich_lab about our recent work led by @XiaoyuChenxy & @fikribirey combining in vitro #assembloid & #organoid models and in vivo transplantation approaches to translate disease biology into potential therapeutics…
This week we welcome the 2025 class of students for our hands-on Stanford @BrOrganogenesis course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to…
Philipp Wörsdörfer (@woephi) and colleagues describe a novel neuro-#mesodermal #assembloid model that recapitulates aspects of peripheral nervous system development, such as #NeuralCrest cell induction, and much more! 📖 Full study in @stemcellreports: bit.ly/43LJ6u2
An insightful spotlight in @NeuroCellPress this week by @Knoblich_lab about our recent work led by @XiaoyuChenxy & @fikribirey combining in vitro #assembloid & #organoid models and in vivo transplantation approaches to translate disease biology into potential therapeutics…
Our three-part, human stem cell-derived cortico-motor #assembloid article is on the cover of Cell @CellPressNews today. Work led by @jimena_andersen @Stanford @StanfordBrain @StanfordBioX @Stanford_ChEMH @cziscience @nyscf @BrOrganogenesis cell.com/cell/fulltext/…
New Resource in the latest issue! #Organoids that resemble the #cerebral cortex or the #hindbrain/spinal cord are assembled with #human skeletal #muscle spheroids to generate 3D cortico-motor assembloids bit.ly/34H4d3I @PascaStanford @Stanford
#3D '#Assembloid' shows how #SARS-#CoV-2 infects Brain Cells Researchers have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2 into the human brain. See more ... buff.ly/3BgbiHr
Immune-Vascular Forebrain #Organoid #Assembloid to model the impacts of APOE genotype (ε2/2 vs 3/3 vs 4/4) on #SARSCOV2 infection Isogenic #hiPSC-derived FOXG1+Nestin+ forebrain neural progenitor➡️ forebrain neuron + astrocyte + oligodendrocyte hiPSC-derived yolk sac➡️…
Led by Benjamin Sharpe (@BSharpeNotFlat), members of the Underwood lab (@TimTheSurgeon) characterized co-culture tumor-derived #organoids and cancer-associated fibroblasts in matrix-embedded #assembloid models of esophageal adenocarcinoma. 👉 bit.ly/3CMwD09
Learning to make #hPSC-derived Cortical #Organoid & Cortico-Pericyte #Assembloid #Pericyte as a secretory source of LIF ⏫Organized architecture of outer radial glia in Neuronal Rosettes @rluongo90 @BaggioliniA @STARProtocols 2024 sciencedirect.com/science/articl…
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation 1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid Beautiful vascular network! Can we further differentiate it into A-C-V microcirculatory unit?😁 @marianamvab bioRxiv 2025…
After months of prep, the Surgical Innovations Unit at @WestmeadHub has finally started lab work! Super exciting! We r developing a novel #PancreaticCancer #assembloid model to understand #metastasis (#cancer spread). Here is our postdoc @Connordoessci and me at our new lab
Today's read is one that you cannot miss! This @Nature paper by Drs. @Sergiu_P_Pasca, @XianglingM, @panagiog, and team highlight the power of a #CRISPR-#assembloid platform to systematically map NDD genes onto human development. Congratulations to all the authors! 🥳🎉
There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in @Nature today, we start tackling this question by combining forebrain #assembloids with CRISPR…
#BiomedicalEngineering: researchers have developed a new kind of organoid that can mimic mature organ architecture and associated tissue microenvironments. The organoid could be used to model intractable diseases and test therapeutic drugs - postech.ac.kr/eng/three-dime… #Assembloid
Drs. @GregScherrer25 and @Sergiu_P_Pasca collaborated to establish a human ascending somatosensory #assembloid from #hPSCs that integrates somatosensory, spinal, thalamic, and cortical #organoids to model the spinothalamic pathway. 🧠 @Nature | go.nature.com/3RLmd56
Dr. Sergiu Pasca @Sergiu_P_Pasca co-organizer of #cshlbrain discussing revolutionary #organoid #assembloid technologies from #stemcells for #neurologicaldisorders #diseasemodeling
#Assembloid: the next trending word in the field of organ and disease modeling? Nice review in @TrendsCellBio via @TGF_fernandes #Organoid and #Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease cell.com/trends/cell-bi…
Early View💡 "Organoids in concert: engineering in vitro models toward enhanced fidelity" by Chunyi Wen et al. @HongKongPolyU @WileyBiomedical #assembloid #biomaterial #microfluidic #organoid Check👉doi.org/10.1002/agt2.4…
New Review📖 "Organoids in concert: engineering in vitro models toward enhanced fidelity" by Chunyi Wen et al. @HongKongPolyU @WileyBiomedical #assembloid #biomaterial #microfluidic #organoid Check👉doi.org/10.1002/agt2.4…
Great lecture by @Sergiu_P_Pasca on #assembloid @UCLchildhealth @DBC_ICH time to generate more assembloid from GI systems… watch this space @GiobbeGiovanni
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