#complement ผลการค้นหา
Novel Treatment Paradigms: #Complement #Inhibition in Antineutrophil Cytoplasmic Autoantibody Vasculitis doi.org/10.1016/j.ekir… #KIRReview #ANCA
🔥#Complement system: the silent orchestrator in #kidney #transplant 🧬Classical→ AMR, C-disease relapse 🌿Lectin→ IRI via DAMPs 💥Alternative→ Xeno & innate triggers ⚙️C3/C5 cleavage→MAC→injury 🛡️Regs: C1-INH, Factor H/I, CD46, CD55, CD59 🔗doi.org/10.1093/ndt/gf… #CKD
There is still time to register now for the inaugural KDIGO GEMs (Guideline Education Meetings) on January 13 and 14! This virtual event, available in multiple time zones, will dive into glomerular diseases, including #ANCA-associated vasculitis, #Complement-mediated kidney…
🚨#Complement Therapy breakthrough in #IgAN Iptacopan slashes proteinuria by 38.3% in Phase 2/3 trials!🎯 ✅ Blocks C3 activation via Factor B ✅ Rapid action (2 weeks) ✅ Safe, no deaths🚫 ✅ Outperforms budesonide Stay tuned for eGFR data📊 📖@KidneyKolumns Jan25 #Nephrology
🔥#Complement in renal allograft injury— immune path of graft loss: 🧬#IRI→ Lectin (MBL/MASPs), DAMP–TLR → cytokines, NK ⚔️#TCMR→ C3a/C5a amplify T/B cells, Th1/Th17↑, Treg↓ 💣#AMR→ DSAs→ classical path→ C4d, MAC, VWF→ injury 🔗 doi.org/10.1093/ndt/gf… #Tx #NephX #MedX
#AugustIssue | Michael Holers describes the #complement system and its role in #rheumatic and #autoimmune diseases, and discusses complement #therapeutics in these settings, as well as prospects for improving their clinical use. go.nature.com/3rVoNvH
Today's card is Temperance Everything has an opposite, and, if the balance is right, they will complement each other perfectly. #balance #complement #opposite #tarot #tarotmessage #LauraJK32
#Complement and #Podocytopathies: Do We Have a New Biomarker? doi.org/10.1016/j.ekir… Original Article: doi.org/10.1016/j.ekir… #KIRCommentary
New #openaccess laboratory study. Does #dexmedetomidine help prevent cognitive decline induced by sleep loss via #complement? #sleepdeprivation #complementactivation #anaesthesia #criticalcare bjanaesthesia.org/article/S0007-…
🤯 Resistant membranous? 🤩 Check out this MABsolutely great Review on future treatment options 💥 Anti #CD20 #CD38 and #complement inhibitors get a special mention… what would your money be on? 👉doi.org/10.1093/ckj/sf… Tweet by @madelena_stauss
Great review paper reporting the promise of complement therapeutics in solid organ transplantation. #TransplantTwitter #Complement #MedTwitter tinyurl.com/3ht36bpk
The #complement #C5 inhibitor #Ravulizumab is a potential new treatment for #IgA nephropathy and proliferative #lupus #nephritis. In a phase 2 trial in IgA nephropathy patients, a statistically significant #proteinuria reduction of −30.1% (90% CI, −43.5% to −13.7%) was…
The role of #complement in #kidneydisease: conclusions from a Kidney Disease: Improving Global Outcomes (#KDIGO) Controversies Conference doi.org/10.1016/j.kint… @UCL @bambinogesu @BUMedicine @unicomplutense @ImperialImmuno @PennKidney @CUDeptMedicine @ClinUnivStLuc #OpenAccess
Out now in @Nature, we find that #GranzymeK activates the entire #complement cascade and contributes to #inflammation across multiple disease states. @Donado_Immuno @AHelenaJonsson1 @BrighamResearch #immunology #rheumatoidarthritis nature.com/articles/s4158…
🧬#Complement Cascade – Inhibitors 🔹C3 inhibitors •Pegcetacoplan→blocks upstream •Iptacopan, Danicopan🛑C3 convertase 🔹C5 inhibitors •Eculizumab, Ravulizumab, Crovalimab🛑C5→prevent MAC (C5b-9) 🧱Natural regulators: • FH, FI,CD55—⛔C3 convertase • CD59⛔ MAC 📌 #PNH
First description of the self-amplifying nature of the #complement alternative pathway. Muller-Eberhard & Gotze, J. Exp. Med. 1972
🩸Hemolysis in PNH 🔴Untreated → IVH via MAC (C5b-9) 🛡️ C5 inhibition → ↓ IVH but ➡️ EVH (C3-opsonized RBCs) ⏱️ PK Breakthrough → ⬇️ drug → ↑ free C5 → IVH ⚠️ PD Breakthrough → complement overload (e.g. infection) → IVH despite drug #PNH #ASH #Complement #HemeTwitter
#thanks for the #complement 3 jobs of complement system Opsinization Pro inflammatory Attack complex #ClinicalPearl #CCRWest24 @ccr
Glad to share this paper @MediPharma_MDPI "#Complement Activation by an Anti-Dengue/Zika #antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement" mdpi.com/2073-4468/12/2…
You look stunning on the left and handsome on the right! #complement #karthikeyathallapally #nobspodcast
Excited to share our recent findings showing essential role of #fibroblast derived #complement C3 in maintaining #Il33- #ILC2 hub during airway #allergy. Congratulations to Ph.D. students @JohnsHopkinsMMI Aishwarya A & Aishwarya M on their first- first author paper 😎
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy dlvr.it/TPZHdq
Réponse de Poutine à une question d'un journaliste sur les raisons de l'exclusion de l'UE des pourparlers de paix en Ukraine par la Russie et les États-Unis : « Ils nourrissaient le fantasme d'infliger une défaite stratégique à la Russie, et tous ces arguments que [les…
Si vous voulez voir un tribunal politique continuez a regarder CNews.. #Complément d'enquête a fait une bonne émission. Les fait sont sourcés. Personne de CNews n'a osé venir.. Probablement parce-que pas d'arguments crédible à opposer..
#Complément d'#enquête #CNews:. se décrédibilisent de façon éclatante, ne citent que des références gouvernementales, propagandistes mensongers de #gauche 24h/24, se sont poignardés eux-mêmes!
#KashPatel is such a clown that stupidity, it's a gift would be a #complement!!! #FBI seeks #interviews with #Democrats who urged US #troops to #defy #illegal #orders yahoo.com/news/articles/…
yahoo.com
FBI seeks interviews with Democrats who urged US troops to defy illegal orders
Democratic lawmakers who appeared in a social media video urging U.S. troops to defy “illegal orders” say the FBI has contacted them to begin scheduling interviews, signaling a possible inquiry into...
Novel Treatment Paradigms: #Complement #Inhibition in Antineutrophil Cytoplasmic Autoantibody Vasculitis doi.org/10.1016/j.ekir… #KIRReview #ANCA
C3 glomerulonephritis - By Roman Praliaud (fellow in Internal Medicine, Dijon, France) #C3GN #complement #alternative #InternistAcademy 2023
🔥#Complement system: the silent orchestrator in #kidney #transplant 🧬Classical→ AMR, C-disease relapse 🌿Lectin→ IRI via DAMPs 💥Alternative→ Xeno & innate triggers ⚙️C3/C5 cleavage→MAC→injury 🛡️Regs: C1-INH, Factor H/I, CD46, CD55, CD59 🔗doi.org/10.1093/ndt/gf… #CKD
#Complement activation and effector pathways in #membranousnephropathy doi.org/10.1016/j.kint… #KIReview #glomerulonephritis #glomerulus #proteinuria
Advice _ of _ the _ day... 🙏🏻💝 God created souls to complement each other. Each soul gives from the source of its strength to the other, Don't look for the #similar, but for the #complement ❤️
🚨#Complement Therapy breakthrough in #IgAN Iptacopan slashes proteinuria by 38.3% in Phase 2/3 trials!🎯 ✅ Blocks C3 activation via Factor B ✅ Rapid action (2 weeks) ✅ Safe, no deaths🚫 ✅ Outperforms budesonide Stay tuned for eGFR data📊 📖@KidneyKolumns Jan25 #Nephrology
#Complement and #Podocytopathies: Do We Have a New Biomarker? doi.org/10.1016/j.ekir… Original Article: doi.org/10.1016/j.ekir… #KIRCommentary
There is still time to register now for the inaugural KDIGO GEMs (Guideline Education Meetings) on January 13 and 14! This virtual event, available in multiple time zones, will dive into glomerular diseases, including #ANCA-associated vasculitis, #Complement-mediated kidney…
Today's card is Temperance Everything has an opposite, and, if the balance is right, they will complement each other perfectly. #balance #complement #opposite #tarot #tarotmessage #LauraJK32
Defining #NephriticFactors as Diverse Drivers of Systemic #Complement #Dysregulation in C3 Glomerulopathy #C3G #VisualAbstract by @DrPallaviPrasad kireports.org/article/S2468-…
Great review paper reporting the promise of complement therapeutics in solid organ transplantation. #TransplantTwitter #Complement #MedTwitter tinyurl.com/3ht36bpk
#AugustIssue | Michael Holers describes the #complement system and its role in #rheumatic and #autoimmune diseases, and discusses complement #therapeutics in these settings, as well as prospects for improving their clinical use. go.nature.com/3rVoNvH
Finally got to meet and listen to the #complement queen 👑!! @WUNephrology is so lucky to have you @anuja_java !! @womeninnephro
New #openaccess laboratory study. Does #dexmedetomidine help prevent cognitive decline induced by sleep loss via #complement? #sleepdeprivation #complementactivation #anaesthesia #criticalcare bjanaesthesia.org/article/S0007-…
The role of #complement in #kidneydisease: conclusions from a Kidney Disease: Improving Global Outcomes (#KDIGO) Controversies Conference doi.org/10.1016/j.kint… @UCL @bambinogesu @BUMedicine @unicomplutense @ImperialImmuno @PennKidney @CUDeptMedicine @ClinUnivStLuc #OpenAccess
Diffuse Endocapillary Glomerulonephritis in a Child With #IL-17RA Deficiency Emphasizes the Pivotal Role of the #Complement Cascade and Anaphylatoxins doi.org/10.1016/j.ekir… #KIRNephrologyRounds
Clinical Safety and Efficacy of #Pegcetacoplan in a Phase 2 Study of Patients with #C3 Glomerulopathy and Other #Complement-Mediated #Glomerular Diseases #VisualAbstract by @jmteakell kireports.org/article/S2468-…
🤯 Resistant membranous? 🤩 Check out this MABsolutely great Review on future treatment options 💥 Anti #CD20 #CD38 and #complement inhibitors get a special mention… what would your money be on? 👉doi.org/10.1093/ckj/sf… Tweet by @madelena_stauss
A new alternative: inhibiting #complement activation in patients with #IgA #nephropathy doi.org/10.1016/j.kint… Original article: doi.org/10.1016/j.kint… @RWTH #KICommentary #IgAN #proteinuria #Iptacopan
Ex-Vivo Test of #Complement Dysregulation in Atypical Hemolytic Uremic Syndrome #aHUS #KidneyTransplant Patients: a Pilot Study #VisualAbstract by @EricAu kireports.org/article/S2468-…
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