#replicationstress search results
Join us for the #Webinar on "Signaling #replicationstress beyond cell boundaries" by Dr. Philippe Pasero @CNRS on 22.07.2022 at 3:00 PM (IST) at @DBT_CDFD @DBTIndia Click the link ▶️lnkd.in/d8grYP4Q to join the You Tube Live streaming. #CDFD
🏅 Highlight from our latest issue: 🧬#FanconiAnemia and #mTOR pathways functionally interact during stalled replication fork recovery 📝By @Indrachaud & colleagues @UMNMorris @nymedcollege @StMarysMD ➡bit.ly/3eFeu6e #replicationstress #metabolism #DNArepair
📢New Recommended Reading #Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al. link.springer.com/article/10.100… #cardiovasculardisease #telomerefragility
My last paper from my postdoc is finally out! 🍾🥂🥳 Thanks to all for your contributions and to @AHA_Research @AHA for my fellowship #Progeria #raredisease #vasculardisease @gonzalo_lab @Progeria @GeroScienceAGE pubmed.ncbi.nlm.nih.gov/36482259/
At last my PhD thesis work in @katerinaVgurova's lab has been published in @oncogenejournal! Our mission was to understand why some cells, but not others, require the histone chaperone FACT. See our findings below! #ReplicationStress nature.com/articles/s4138…
I’m looking for a female researcher, working with #telomeres or #replicationstress or #genomeinstability for a project proposal. I’d be pleased to get in touch with #blackwomeninSTEM #transgenderinSTEM and non-first English speakers as well. @AcademicChatter @FranklinWomen
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance ➡️ buff.ly/4kloIII #FOXM1 #ReplicationStress #DNAdamage
Replication stress indeed triggers cellular senescence, accelerating aging. Studies show cells with induced replication stress age faster, with a 50-60% increase in senescence markers like p16INK4a. #CellularAging #ReplicationStress
Online! 🖥️ Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant #ERα expression and proliferation in luminal primary and metastatic #breastcancer cells Full text 👇 jeccr.biomedcentral.com/articles/10.11… #ReplicationStress @IREISGufficiale
Research article from our Biochemical Journal ‘BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress’ bit.ly/BiochemJ-BAP1 #cancer #genome #ReplicationStress #epigenetics
ICYMI: online now @NatureCancer: Sonic hedgehog accelerates DNA replication to cause #ReplicationStress, promoting cancer initiation in #medulloblastoma - by @Fred_Charron & co. Read it here: go.nature.com/3hxP3BM rdcu.be/b5NNl
🚨 Targeting replication stress in cancer therapy. Current and emerging approaches, from preclinical and biomarker development to clinical trial evaluation. @Nature 👇🏻 doi.org/10.1038/s41573… #cancertherapy #replicationstress #targetedtherapy #biomarkers #precisiononcology
Can targeting the very thing that makes cancer grow -- its ability to replicate rapidly -- provide treatment options for ovarian and uterine cancers? See what researchers have discovered. #ReplicationStress #OvarianCancer #UterineCancer ms.spr.ly/6010l8zuA.
☕️In this issue: @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING. @manorlaboratory 👉🏾rdcu.be/dyV6K nature.com/articles/s4155…
nature.com
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid...
Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...
Each #SMARCB1-deficient malignancy is driven by >1 pathways. #replicationstress itself manifests differently confering distinct vulnerabilities. Tissues from our trial (bit.ly/3fbxW8E) are used to uncover primary & acquired mechanisms of resistance in RMC. Stay tuned.
💫NEW: @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING. @manorlaboratory, @salkinstitute 👉🏾rdcu.be/dyV6K nature.com/articles/s4155…
New Review 🎯 𝐓𝐡𝐞 𝐦𝐮𝐥𝐭𝐢𝐟𝐚𝐜𝐞𝐭𝐞𝐝 𝐫𝐨𝐥𝐞𝐬 𝐨𝐟 #𝐜𝐨𝐡𝐞𝐬𝐢𝐧 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 Enjoy your reading 🔍 jeccr.biomedcentral.com/articles/10.11… #DNArepair #ReplicationStress #GenomeInstability @IREISGufficiale
ICYMI: #HDACi Target #DNAReplication Regulators and #ReplicationStress in #EwingSarcoma Cells. This study adds important data to the field on the Ewing sarcoma epigenome, particularly targetable vulnerabilities that may be exploitable in the clinic. doi.org/10.1158/2767-9…
🧬 FOXP1 has a non-transcriptional role in replication stress. CHK1 phosphorylation vs O-GlcNAcylation fine-tunes ATR activation. 👉 ubigene.us/application/fo… #ReplicationStress #ATR #DNARepair #CRISPR
#EwingSarcoma is an aggressive pediatric tumor characterized by elevated levels of #ReplicationStress. Martin et al discuss the current state of knowledge and possible therapeutic interventions in their #ReviewArticle. @RoswellPark bit.ly/2SN0dIH
ICYMI: #HDACi Target #DNAReplication Regulators and #ReplicationStress in #EwingSarcoma Cells. This study adds important data to the field on the Ewing sarcoma epigenome, particularly targetable vulnerabilities that may be exploitable in the clinic. doi.org/10.1158/2767-9…
Recently published: #HDAC Inhibitors Target #DNAReplication Regulators and #ReplicationStress in #EwingSarcoma Cells, by Stacia L. Koppenhafer et al. doi.org/10.1158/2767-9… @UIchildrens @IowaNeuroPharm @IntMedatIowa #HDACi #OpenAccess
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance ➡️ buff.ly/4kloIII #FOXM1 #ReplicationStress #DNAdamage
Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). biorxiv.org/content/10.110… #replicationstress #DNArepair #ATR #replication #DNA #RPA
🧬Looking forward to the #DNAreplication meeting @embl 'ATC' (Advanced Training Centre) in Heidelberg 🎙Today's session features talks on 🔎#ReplicationStress 🔎#ReplicationFork stability #EESreplication @EMBLEvents
Replication stress indeed triggers cellular senescence, accelerating aging. Studies show cells with induced replication stress age faster, with a 50-60% increase in senescence markers like p16INK4a. #CellularAging #ReplicationStress
Can targeting the very thing that makes cancer grow -- its ability to replicate rapidly -- provide treatment options for ovarian and uterine cancers? See what researchers have discovered. #ReplicationStress #OvarianCancer #UterineCancer ms.spr.ly/6010l8zuA.
#PARPi leads to accumulation of ssDNA gaps in POLE4 KO, due to impaired post-replicative repair. This induces #replicationstress phenotypes mediated by ATR and DNA-PK. Consequently, POLE4 KO are hypersensitive to ATRi and its combination with PARPi.
☕️In this issue: @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING. @manorlaboratory 👉🏾rdcu.be/dyV6K nature.com/articles/s4155…
nature.com
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid...
Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...
💫NEW: @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING. @manorlaboratory, @salkinstitute 👉🏾rdcu.be/dyV6K nature.com/articles/s4155…
❗️Now in Early View PPM1D activity promotes the replication stress caused by cyclin E1 overexpression 🔗buff.ly/3tE5U1c #PPM1D #ReplicationStress #PrecisionOncology #CellCycle #CCNE1
🚨 Targeting replication stress in cancer therapy. Current and emerging approaches, from preclinical and biomarker development to clinical trial evaluation. @Nature 👇🏻 doi.org/10.1038/s41573… #cancertherapy #replicationstress #targetedtherapy #biomarkers #precisiononcology
1/💡 New DNA Damage Response (DDR) Target: CAD Caspase-activated DNase Scientists are researching a concept called 'synthetic lethality' as a potential way to target and kill cancer cells by exploiting their DNA damage. #cancer #DDR #replicationStress science.org/doi/10.1126/sc…
📢New Recommended Reading #Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al. link.springer.com/article/10.100… #cardiovasculardisease #telomerefragility
My last paper from my postdoc is finally out! 🍾🥂🥳 Thanks to all for your contributions and to @AHA_Research @AHA for my fellowship #Progeria #raredisease #vasculardisease @gonzalo_lab @Progeria @GeroScienceAGE pubmed.ncbi.nlm.nih.gov/36482259/
Mild replication inhibition, TOP1 restoration as well as R-loop restoration, all rescue replication dynamics and DNA damage. Interestingly, high TOP1 expression is also associated with replication-induced mutagenesis in cancer. #replicationstress #rloops #topoisomerase1
🏅 Highlight from our latest issue: 🧬#FanconiAnemia and #mTOR pathways functionally interact during stalled replication fork recovery 📝By @Indrachaud & colleagues @UMNMorris @nymedcollege @StMarysMD ➡bit.ly/3eFeu6e #replicationstress #metabolism #DNArepair
Join us for the #Webinar on "Signaling #replicationstress beyond cell boundaries" by Dr. Philippe Pasero @CNRS on 22.07.2022 at 3:00 PM (IST) at @DBT_CDFD @DBTIndia Click the link ▶️lnkd.in/d8grYP4Q to join the You Tube Live streaming. #CDFD
Online! 🖥️ Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant #ERα expression and proliferation in luminal primary and metastatic #breastcancer cells Full text 👇 jeccr.biomedcentral.com/articles/10.11… #ReplicationStress @IREISGufficiale
ICYMI: online now @NatureCancer: Sonic hedgehog accelerates DNA replication to cause #ReplicationStress, promoting cancer initiation in #medulloblastoma - by @Fred_Charron & co. Read it here: go.nature.com/3hxP3BM rdcu.be/b5NNl
Become a #DNAdamageresponse expert in no time with our latest interactive poster – summarizing the key targets involved in DDR both from endogenous and exogenous sources. Download now: bit.ly/3moEW4o #ReplicationStress #cancer #DNArepair
Research article from our Biochemical Journal ‘BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress’ bit.ly/BiochemJ-BAP1 #cancer #genome #ReplicationStress #epigenetics
Can targeting the very thing that makes cancer grow -- its ability to replicate rapidly -- provide treatment options for ovarian and uterine cancers? See what researchers have discovered. #ReplicationStress #OvarianCancer #UterineCancer ms.spr.ly/6010l8zuA.
Dysregulation of cell extrusion is linked to various diseases, including cancer, but it is not well understood—until now. Scientists show that #replicationstress induces cell extrusion, and they propose that extrusion serves a tumor-suppressive function. ow.ly/3VOz50EJccu
🚨 Targeting replication stress in cancer therapy. Current and emerging approaches, from preclinical and biomarker development to clinical trial evaluation. @Nature 👇🏻 doi.org/10.1038/s41573… #cancertherapy #replicationstress #targetedtherapy #biomarkers #precisiononcology
Genomic Instability in Cancer | Targeting #ReplicationStress ATR Pathway in Cancer: Biology and BioMarkers | REVIEW | Oscar Fernandez-Capetillo @CNIO_Cancer @NatureRevCancer buff.ly/2My7oQM
New Review 🎯 𝐓𝐡𝐞 𝐦𝐮𝐥𝐭𝐢𝐟𝐚𝐜𝐞𝐭𝐞𝐝 𝐫𝐨𝐥𝐞𝐬 𝐨𝐟 #𝐜𝐨𝐡𝐞𝐬𝐢𝐧 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 Enjoy your reading 🔍 jeccr.biomedcentral.com/articles/10.11… #DNArepair #ReplicationStress #GenomeInstability @IREISGufficiale
Special Issue "#DNA #ReplicationStress" mdpi.com/journal/ijms/s… #GuestEditor: Dr. Robert M. Brosh Jr. (#NIH, USA) @IRPatNIH
1/💡 New DNA Damage Response (DDR) Target: CAD Caspase-activated DNase Scientists are researching a concept called 'synthetic lethality' as a potential way to target and kill cancer cells by exploiting their DNA damage. #cancer #DDR #replicationStress science.org/doi/10.1126/sc…
📢New Recommended Reading #Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al. link.springer.com/article/10.100… #cardiovasculardisease #telomerefragility
My last paper from my postdoc is finally out! 🍾🥂🥳 Thanks to all for your contributions and to @AHA_Research @AHA for my fellowship #Progeria #raredisease #vasculardisease @gonzalo_lab @Progeria @GeroScienceAGE pubmed.ncbi.nlm.nih.gov/36482259/
🧬Looking forward to the #DNAreplication meeting @embl 'ATC' (Advanced Training Centre) in Heidelberg 🎙Today's session features talks on 🔎#ReplicationStress 🔎#ReplicationFork stability #EESreplication @EMBLEvents
ICYMI: #HDACi Target #DNAReplication Regulators and #ReplicationStress in #EwingSarcoma Cells. This study adds important data to the field on the Ewing sarcoma epigenome, particularly targetable vulnerabilities that may be exploitable in the clinic. doi.org/10.1158/2767-9…
#EwingSarcoma is an aggressive pediatric tumor characterized by elevated levels of #ReplicationStress. Martin et al discuss the current state of knowledge and possible therapeutic interventions in their #ReviewArticle. @RoswellPark bit.ly/2SN0dIH
❗️Now in Early View PPM1D activity promotes the replication stress caused by cyclin E1 overexpression 🔗buff.ly/3tE5U1c #PPM1D #ReplicationStress #PrecisionOncology #CellCycle #CCNE1
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance ➡️ buff.ly/4kloIII #FOXM1 #ReplicationStress #DNAdamage
Recently published: #HDAC Inhibitors Target #DNAReplication Regulators and #ReplicationStress in #EwingSarcoma Cells, by Stacia L. Koppenhafer et al. doi.org/10.1158/2767-9… @UIchildrens @IowaNeuroPharm @IntMedatIowa #HDACi #OpenAccess
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