Brett Chrest
@Chrest_brett
PhD student with expertise in Mitochondrial Bioenergetics & Cancer Metabolism with @KFW_Lab┃ Focus: SUCL Enzymes, Respiratory & Energy Limitations in AML🩸
You might like
📢New @KFW_Lab paper out! AML mitochondria remain unperturbed & phenotypically stable under diverse nutrient conditions. And rather than specific nutrients or physiological relevance, AML cell proliferation is influenced by the complete nutrient profile 👉 cancerandmetabolism.biomedcentral.com/articles/10.11…
Dr. Ross Levine (@rosslevinemd), Senior Vice President of Translational Research at MSK, has been named MSK's new Chief Scientific Officer (CSO). Dr. Levine will be responsible for setting and leading strategy for basic and translational research, including programs, centers,…
This⬇️ we are literally a mitochondrial lab and even we don’t just think about mitos
The mitochondria explain everything cult is my favorite one...
Cell respiration is critical, but it is very hard to kill AML cells by inhibiting respiration. Respiration is not the target.
Cellular acyl-CoA profiling reveals SLC25A42/SLC25A16 in #mitochondria import and #metabolism @NatMetabolism rdcu.be/eN5N4
There’s a profound lesson for life here. You can beat yourself up. You can—and should—dwell on the thing for a bit. It’s supposed to sting; that means you care. But at some point, you have to remember that you were in the arena, making the best call you could with the…
Big shoutout to the folks over at @FUTURUMCareers for highlighting our work exploring the role of the mitochondria in blood cancers. It was an absolute pleasure to work with such a great team! futurumcareers.com/cancer-biology…
How do dividing cells maintain mtDNA euploidy? Sharing new work by Sneha Rath that shows how the proton motive force (PMF) acts as a "puppeteer" to balance cell proliferation & mtDNA replication to maintain a stable mtDNA copy number. biorxiv.org/content/10.110…
Faeth Therapeutics' $92 Million Total Funding Powers PIKTOR Phase 2 Following 80% Response Rate in Endometrial Cancer 👀 businesswire.com/news/home/2025…
Good work here. Concentrations vs fluxes.
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism cell.com/cell-metabolis…
Human muscle cells incorporate glucose into proteins, RNA, and lipids, and anabolic stimulation further increased these processes. Resistance training increased metabolites and enzymes of these processes, e.g., PHGDH, which was shown to be anabolic. tinyurl.com/2744e22s
Congratulations to @DrTonyLetai on being named the new director of @theNCI. An internationally renowned researcher and oncologist, Letai has helped shape our understanding of cancer through his study of cell death. His appointment is a testament to our continuing commitment to…
"A drug–diet combination could improve childhood cancer treatment". Arginine and proline. Bravo 👏 nature.com/articles/s4158…
Protein clearance rates vary across proteins in inverse proportion to the average cell-type doubling rate. This explains the degree to which protein clearance (degradation) sets protein abundance. biorxiv.org/content/10.110…
Despite the benefits of a Ketogenic Diet in reducing body weight, over long time, it can lead to dyslipidemia, fatty liver, and glucose intolerance in mice. science.org/doi/epdf/10.11…
An Amazing Cancer Biology Department Driving Advances Across @advocatehealth - Ruben Mesa (@mpdrc) oncodaily.com/blog/ruben-mes… #OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #CancerBiology @CancerWorldmag
Slight caution: Labeling glutamine, blocking glutaminase, and *only* looking at labeled extracellular succinate might not give clear insight into the mitochondrial pathway. AKG can be exported & converted to succinate outside of the mito. nature.com/articles/s4146…
And here how brain tumors exploit glucose for their growth, along with a dietary restriction of an amino acid therapy to prevent it nature.com/articles/s4158…
United States Trends
- 1. Panthers 20K posts
- 2. Syracuse 5,799 posts
- 3. Comey 204K posts
- 4. GeForce Season 4,512 posts
- 5. 49ers 23K posts
- 6. #KeepPounding 3,151 posts
- 7. Mark Kelly 138K posts
- 8. #FTTB 2,511 posts
- 9. Everton 150K posts
- 10. St. John 8,937 posts
- 11. Roman Reigns 5,915 posts
- 12. Niners 2,989 posts
- 13. Nick Scott N/A
- 14. Genesis Mission 3,946 posts
- 15. UCMJ 20.5K posts
- 16. Monday Night Football 6,673 posts
- 17. #CARvsSF N/A
- 18. Benedict Arnold 4,775 posts
- 19. Muni Long N/A
- 20. #90dayfiancetheotherway N/A
You might like
-
Herman Pontzer
@HermanPontzer -
Shaun Ward
@MyNutritionSci -
Emily Dhurandhar, Ph.D.
@EmilyDhurandhar -
Jens Lund
@jens_lund -
Kelsey Fisher-Wellman, PhD
@KFW_Lab -
Cathy Breen PhD RD
@cathybreen24 -
Peter Aldiss, PhD
@Peter_Aldiss -
Pissed Off PT
@PissedOff_PT -
Tom Babington
@Tom_Babington1 -
Jim Johnson, PhD
@JimJohnsonSci -
Kros
@krosenque -
Jake Mey, PhD, RD
@CakeNutrition -
Austin Hogwood, PhD
@Hogwood_AC -
John Thyfault (TeeFo)
@john_thyfault -
Book Baddie 📚🐛
@_Lahnic_
Something went wrong.
Something went wrong.