Diego Martins
@dap_martins
PhD student at the Schuringa Lab - CRCG. Researcher focused on molecular markers of therapy response in Myeloid Leukemias.
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Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data nature.com/articles/s4146…
Excited to announce a new paper in @CD_AACR with @junwei_s, @TomZhendong, @DaniyanMd and led by @PuZhang09980432. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in AML: aacrjournals.org/cancerdiscover…
Review from the lab on lipid metabolism in AML just out @LeukemiaJnl rdcu.be/em651 Led by the hard work of @VilmaDembitz and @sophiejamess_ Hope you enjoy the read!
Register now for the FEBS Workshop on the Molecular and Cellular Pathways of Aging in Hematopoiesis that will take place in Crete on October 20-24, 2025! To register visit: …inginhematopoiesis2025.febsevents.org
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!
Fantastic talk from Dr. Zheng from the @QuekLab on the role of TP53 mutations in CH-associated dyserythropoiesis and OxPhos alterations!
So happy to present our work at the #ASH24! I’m very honoured to be a recipient of the abstract achievement award this year. Many thanks to all the collaborators involved in this project @SchuringaLab @QuekLab @FrezzaLab @jeansarry
Fantastic talk from Manuela at #ASH2024 on the role of autophagy in FLT3-inhibitor therapy in AML! Great collaboration of the Traina Lab at @fmrpusp and @SchuringaLab ! Very well done!
Great ending for the first day at #ASH2024 with this group that keeps growing every year! Great to see you all! @SchuringaLab @QuekLab
We are at the #ASH2024! Check out today poster #1393 about the role of lipid metabolism in metformin sensitivity in AML from @dominiqueasr and #1539 with the mechanisms of MLL5-driven leukemic transformation from @luisesimoes
I’m excited to share an R package that we’ve created for mapping scRNA-seq data across normal and malignant hematopoiesis! We've used this to identify hematopoietic stem cells from healthy tissues and map leukemia cells from hundreds of patients. 1/6 github.com/andygxzeng/Bon…
Why do AML patients with African ancestry have poor outcomes? Fascinating results indicate that genetics alter AML biology. Also, its Bailee Kain's first co-first author postdoc pub. @Bailee_Kain @AkEisfeld @nsalomonis and Elaine Mardis nature.com/articles/s4158…
CH in Telomere biology disorders as predictors of #MDS! As Chr1q+, U2AF1-S34 leads to TP53 pathway deregulation in HSCs with dysfunctional telomeres. Now online! #TBD #clonalHematopoiesis
The clonal landscape is dominated by mutations in PPM1D, POT1, TERTp and U2AF1. Patients who develop U2AF1, TP53, or chromosome 1q gain, have a higher risk of cancer development.
🔎 Investigators with Dr. @VilmaDembitz at @QMBCI identified stearoyl-CoA desaturase as prognostic of patients' outcomes and showed that SCD inhibition ⛔ is a therapeutic vulnerability across multiple #AML models. @LeukemiaJnl | go.nature.com/4g44ssH
WE’LL NEVER FORGET THIS MOMENT 🥹 An all-Black podium graces #OlympicGames gymnastics for the first time ever.
Wish you could quickly analyze your #singlecell data? Or easily share these large datasets with collaborators? Good news! We just launched our free web-based app 10x Genomics Cloud Analysis globally! Sign up now or explore a guided walkthrough: bit.ly/4cpHhae
Finishing #EHA2024 with this amazing opportunity to present our latest results on MN1-driven AMLs! Very grateful to the @EHA_Hematology scientific committee, to my mentor @SchuringaJan and all the members of the @SchuringaLab, @QuekLab and #RegoLab that contributed to this story!
Amazing talk summarizing all the old and new directions regarding mitochondrial/lipid metabolism in drug resistant AMLs from @jeansarry at #EHA2024!
Fantastic talk from @SchuringaJan on the latest data from the @SchuringaLab about the metabolic heterogeneity in AMLs and the role of the tumor microenvironment on metabolic abnormalities/adaptation in AML at #EHA2024!
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