Cornelius Gati
@CorneliusGati
Assistant Professor @USC. Structural biologist studying biophysics and pharmacology of GPCRs.
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Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…
Structural biology is evolving fast! To spotlight this exciting progress, @jbiolchem associate editors curated a thematic review series on supramolecular structures: ow.ly/yWIc50XveNB. #JBiolChem #ASBMBJournals
New paper! This is the marquee effort of my talented student Jessy Bowden, who identified a unique role for Src kinase signaling in microglia for promoting opioid signal transduction and pain relief in the spinal cord. Congrats Jessy! journals.lww.com/pain/fulltext/…
#Research Reading: #Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation pnas.org/doi/10.1073/pn…
Exciting holiday present for the Gupta lab! 🎉 🎊 Our paper "Molecular mechanism of substrate transport by human peroxisomal ABCD3" is now published in Proceedings of the National Academy of Sciences!! 🎉 🎊 @PNASNews pnas.org/doi/10.1073/pn…
Congratulations to the 2025 ASPET Fellows! The FASPET designation is a prestigious honor bestowed on the Society’s most distinguished members. We recognize them for their achievements in pharmacology! Meet the 2025 FASPET class: aspet.org/aspet/meetings…
Honored and excited to be part of this group of ASPET Fellows #ASPET
Congratulations to the 2025 ASPET Fellows! The FASPET designation is a prestigious honor bestowed on the Society’s most distinguished members. We recognize them for their achievements in pharmacology! Meet the 2025 FASPET class: aspet.org/aspet/meetings…
I’m excited to share that I’ve joined the Editorial Board of the Journal of Biological Chemistry (@jbiolchem). I look forward to serving this incredible community journal and engaging with exciting science! @ASBMB
Definitive evidence of how Narcan works by capturing images of it in action for the first time. May help develop drugs with longer-lasting protection against overdose. Great work and writing by Saif Khan, Ph.D. Candidate in Biology @USCDornsife dornsife.usc.edu/news/stories/h…
#カガク。#生体分子。#分子。GPCR。Nature ハイライト「構造生物学：μオピオイド受容体でのGDP放出を捉える」 natureasia.com/ja-jp/nature/h… PDBデータ9PXU・9PXW・9PXX・9PXY・9PXV・9PY2・9PY3・9PY4。
Congratulations to the team for discovering and publishing a distinct, robust, and selective C3–C4 bond isomerization available to sulfonyl amino DASAs! Read more here, pubs.rsc.org/en/content/art…
Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.1…
New paper from @schulte_lab spearheaded by @MagdalenaScharf discovering FZD-targeting negative allosteric modulators. Julia Kinsolving was instrumental for the CryoEM structure of FZD7 with the NAM bound. Fantastic team work @GraetzLukas @JanVo12 @bforsb nature.com/articles/s4146…
They grow up so fast! Many congratulations to the newly minted Dr. Saif Khan, the first graduate of our lab. 🎓 He delivered a spectacular defense on our recent work in opioid receptor pharmacology. We’ll miss you greatly and wish you every success in your next chapter! @sfk_usc
Christmas came early this year! Our group will be looking for a Postdoc soon. Reach out if you're interested in the structural pharmacology of opioid receptors, or know anyone who might be.
Last paper this year, thanks to all involved! - AMPA receptors continue to surprise.. science.org/doi/10.1126/sc…
Excited to have this paper out in @PNASNews, where we interrogate the induction mechanism of rapid homeostatic signaling at synapses. Congrats to @ChengjieQ and the rest of the team! pnas.org/doi/10.1073/pn…
Synapses are more resilient than you might think! 💪When GluRs are weakened, the presynaptic neuron can compensate by releasing more neurotransmitters, keeping synaptic strength in a stable range. This retrograde process is called presynaptic homeostatic potentiation (PHP). 1/
Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…
Are you working on #GPCRs, #transporters, or #channels? Join us in beautiful Tuscany in March 2026 for the GRS & GRC Ligand Recognition and Molecular Gating! Early career researchers - don’t miss the chance to apply for an oral presentation; the deadline is December 7th.
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry jbc.org/article/S0021-…
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