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Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy. nature.com/articles/s4146…
nature.com
Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic...
Nature Communications - Inflammasome assembly promotes the cleavage and oligomerisation of gasdermin D (GSDMD) and subsequent pore formation. Here the authors raise nanobodies to human gasdermin...
Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. biorxiv.org/content/10.110…
How could we identify key genes involved in any biological process and cell type? Please read on about Nuclear In-Situ Sequencing (NIS-Seq) nature.com/articles/s4158…
and so it begins.....science needs to start getting serious about how how to deal with this type of attacks, sowing distrust.
RFK Jr. Dismantles Journalist's Appeal to Authority Journalist: "You're a lawyer and activist, not a doctor or scientist." RFK Jr.: "Relying on experts is akin to religious faith and totalitarianism. In a democracy, we question everyone."
Check out Lisa‘s take on her recent paper on the mechanism (and potential therapeutic targeting) of #GSDMD pore formation using #nanobodies.
🎬 Episode 11 of #SpotOnScience is out! In this episode, Lisa Schiffelers from the group of @FISchmidtLab shares insights into her work on unraveling gasdermin D (GSDMD) pore formation using nanobodies. 👩🔬 Check out the episode: youtube.com/watch?v=HvgNf5…
It is out! #NanoPlex is the universal strategy for multiplexing any immunofluorescence using erasable #nanobodies from @_NanoTag_. We showcase easy multiplexed STED, STORM, and 21-plex Confocal #Microscopy. Published in @NatureComms here: rdcu.be/dWvzO
😯😯
It is out! #NanoPlex is the universal strategy for multiplexing any immunofluorescence using erasable #nanobodies from @_NanoTag_. We showcase easy multiplexed STED, STORM, and 21-plex Confocal #Microscopy. Published in @NatureComms here: rdcu.be/dWvzO
Teaching the next generation of scientists all about what we do in the lab #TürenaufmitderMaus – big thank you to my whole lab and, in particular, Fabian @IIIBonn @for5547 #sfb1454 @ImmunoSens
Epic effort from Flo & first author Lisa Schiffelers of @FISchmidtLab . Antagonistic camelid #nanobodies are small enough to traverse early #GSDMD pores to inhibit further #pore #formation. Monomers target the membrane, suggesting #monomer to #oligomer transition on #membrane.
Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy. nature.com/articles/s4146…
nature.com
Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic...
Nature Communications - Inflammasome assembly promotes the cleavage and oligomerisation of gasdermin D (GSDMD) and subsequent pore formation. Here the authors raise nanobodies to human gasdermin...
✨Today officially marks 10 years of @TheDohertyInst. From pioneering research on the immune system to our response to COVID-19, we’re incredibly proud of our staff and students and their achievements in infection and immunity. And a huge thank you to our supporters. Here’s to…
Honored to win the Alessandro Moretta Memorial Award. Fantastic science in a wonderful setting in Greece. @ragoninstitute @harvardmed @AegeanConf
Congratulations to colleague and friend Charles Evavold (pictured on the right) on winning the Alessandro Moretta award at the 19th Innate Immunity @AegeanConf!
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