GeertCarmelietLab
@GeertLab
Skeletal cell metabolism and hypoxia signaling in bone development, regeneration and bone disorders @KU_Leuven
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Big congratulations @SLoopmans for your excellent PhD research!! This is one of the best moments as a mentor to see the success of team members. Many thanks to all co-authors and everyone in our research team as well as funding by @FWOvlaandere and @KU_Leuven!!
Very happy to share the final chapter of my PhD Research with @GeertLab, now online in @NatMetabolism, revealing that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival to ensure chondrocyte functioning and bone lengthening (1/4)
Very happy to share the final chapter of my PhD Research with @GeertLab, now online in @NatMetabolism, revealing that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival to ensure chondrocyte functioning and bone lengthening (1/4)
It was a great pleasure to edit this book👇 with Antonio Rossi. It describes how the #ECM is altered in inherited skeletal disorders like #osteogenesis imperfecta, #achondroplasia, #Marfan, #EDS etc. thanks to @aforlino @KasiaPirog1 @mamareen8 @WannAngus and many others
🚨 Abstract Submissions Closing Soon! 🚨 Submit by 14 Jan 2025 for the opportunity to present in Innsbruck and win a Grant or Award! 🏆 Details & guidelines on the congress website. 👉 buff.ly/49L1fvi #AbstractSubmission #ECTS2025 #BoneResearch
🚨 Abstract submissions for ECTS 2025 Congress are open until 14 Jan 2025! Be part of Europe’s top musculoskeletal research event, May 23–26, 2025 in Innsbruck, Austria. Share your work & connect with experts! Details: ernbond.eu/2024/11/28/ect… #ECTS2025 #ERNBOND #EU4Health
Many thanks @NatMetabolism for publishing and highlighting our research, all members of our lab, the excellent collaboration with @bernthie and especially first author @SteveStegen
Top Citations 2024: #20🏆✨ @GeertLab (@KU_Leuven) and co-authors describe the role of the serine synthesis pathway in osteoclast differentiation through #epigenetic regulation of NFATc1 expression 🦴🧫 nature.com/articles/s4225…
nature.com
The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of...
Nature Metabolism - Stegen et al. show that serine metabolism is transiently upregulated during osteoclastogenesis, and it drives osteoclast differentiation via epigenetic regulation of NFATc1...
ECTS Academy applications are now OPEN! Basic Call: buff.ly/3QpM8hU Clinical Call: buff.ly/3u09mDE Deadline: 7 January 2025
Do you want to contribute in ECTS activities? Be part of the ECTS Committees and their Action Groups! If you would like to engage with ECTS and be part of our activities, let us know who you are and your skills by submitting the form in the link! buff.ly/3N2qU87
Congratulations @vishalmkrishnan and @ralfhadams for this beautiful work, linking the regional differences in #vasculature with the #metabolic heterogeneity of the bone microenvironment.
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". Excited to share my PhD work from @ralfhadams lab, now published in @NatureCellBio. nature.com/articles/s4155… 🧵1/8👇 🐭🔬🦴
The not-to-be-missed course in the metabolic bone disease topic is the Clinical Training Course, taking place online🧑💻on 15 November and 18 November from 8:30-5:00PM CET. Register today: buff.ly/3R5N50L
"Cellular ATP demand creates metabolically distinct subpopulations of mitochondria" nature.com/articles/s4158…
Congratulations Rik and @SilviaMonteag : interesting interaction between important signaling pathways!
New @NatureComms Publication Alert! We uncover a Wnt/IGF1 link driving joint damage in #osteoarthritis. IGF1, induced by Wnt signaling, worsens the joint disease, but IGF1 targeting could open doors to new therapie. rdcu.be/dXZ7l @SilviaMonteag @AnaEscribano7 1/14
It was a pleasure being in your thesis committee and discussing the numerous interesting findings
It has been an incredible journey! Thanks to @FendtLab and my PhD thesis committee @GeertLab @CoolsJn @CorbetCyril @MariaRodrColman for their support and the amazing discussion! @FWOVlaanderen @komop_tgkanker @KU_Leuven @vib_ccb
In @CellStemCell: a tribute to Charles “Chuck” K.F. Chan (1975–2024). Thank you Tom Ambrosi and Mike Longaker for remembering a brilliant and kind scientist and @StanfordMed colleague gone far too soon: sciencedirect.com/science/articl…
Excellent presentation by @SteveStegen on serine #metabolism in #bone: cell types and outcome matters!!
Many thanks Lydia!! @Lydfinley
Excellent, inspiring and concept-broadening Keynote presentation of Lydia Finley !!! Great start of the day.
Excellent, inspiring and concept-broadening Keynote presentation of Lydia Finley !!! Great start of the day.
Learning about metabolic control of healthy and pathological skeletal cells and their microenvironment at #ASBMR2024 Pre-meeting
Will be great to have all these updates on #bone cell #metabolism at the #ASBMR2024 premeeting
Off to #asbmr2024! Looking forward sharing our findings on how the #serine synthesis pathway regulates #bone cell function at the energy #metabolism pre-meeting on Thursday! @ASBMR @GeertLab
looking forward to all these presentations!! And the metabolism pre-meeting will be interesting.
Off to #asbmr2024! Looking forward sharing our findings on how the #serine synthesis pathway regulates #bone cell function at the energy #metabolism pre-meeting on Thursday! @ASBMR @GeertLab
Congratulations Courtney!! Interesting findings. See you in Toronto #ASBMR2024
Happy to be able to share our latest findings about glutamine metabolism in osteoclasts! Glutaminolysis provides nucleotides and amino acids to regulate osteoclast differentiation in mice | EMBO reports embopress.org/doi/full/10.10…
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