Szymon W. Manka
@LabManka
Structural biology of prions @ImperialInfect views my own
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As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science science.org/doi/10.1126/sc…
MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....
We're hiring for a Head of Department to lead one of Europe’s largest and most impactful centres for infectious disease research — right here at @imperialcollege. We're looking for a strategic leader with vision and drive. Apply by 15 September👇 imperial.ac.uk/jobs/search-jo…
Please RT 🙏 If you’re an ECR working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial, London. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships imperial.ac.uk/media/imperial…
🇺🇸 CHATGPT JUST GOT HANDS AND A CALENDAR Forget answering questions. GPT just learned how to do things. OpenAI’s new agent can now browse the web, click, scroll, shop, and even book your boat day in St. Tropez. It plans, compares, buys, and yes, it’ll build your group trip…
“HUMANITY HAS PREVAILED (FOR NOW)” - CODER BEATS OPENAI IN WORLD FINALS A Polish programmer named “Psyho” just beat OpenAI’s model in a 10-hour coding showdown at the AtCoder World Finals in Tokyo. The challenge? Code the smartest way to guide a bunch of robots across a grid…
So glad to be invited to speak at the FASEB Protein Aggregation: Polymorphic Species conference - a real privilege to be among such thoughtful voices. Thank you for having me and I am looking forward to the conversations. events.faseb.org/event/protein-…
Recently out! An awesome commentary on our bacterial ESCRT-III work rdcu.be/ei98N - big thanks to John McCullough and Wes Sundquist for this. And of course big shout out to #NSMB for the tasty cover!
We developed a new siRNA drug candidate for prion disease, a @broadinstitute / @RTI_UMassChan collaboration. We now have an open IND meaning FDA has given us permission to start first-in-human trials. Work remains before trials can launch. The full update: cureffi.org/2025/04/14/ope…
If you crave to prove your beloved hypothesis, you'll always find a way to do so - and you'll *almost* always be wrong. (For the same reason, even the most brilliant intuition will never be as powerful as hypothesis-free genome-wide perturbation).
12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak
Thanks @ISN_society for the shoutout and great summary! linkedin.com/posts/internat…
This may be the structural basis for interspecies transmission barriers, but it also suggests that these barriers are not absolute, and can be overcome.
In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! onlinelibrary.wiley.com/doi/full/10.11…
In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! onlinelibrary.wiley.com/doi/full/10.11…
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