Keith Robison
@OmicsOmicsBlog
Computational biologist in drug discovery since '96.
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Lilly spends 25% of revenue on R&D as a rule, so about $18.6B R&D spend expected in 2026 equal to 2/3 of the whole NIH budget. Lots of dough for partnerships and M&A to go back into the ecosystem - folks talk about this far less than patent expiry related M&A spend but this…
To sustain the valuation, Lilly would have to re-invest staggering amounts of capital back into the ecosystem over the next few decades. Very few things in the past 30 years have happened that can shape the industry at that scale. More importantly, Lilly is the first pharma I’ve…
This needs to be disseminated far and wide. This “28 point plan” is nothing more than Russia’s absurd wish list that should be dismissed and shredded for the garbage that it is. The only peace plan that should be taken seriously is one that is 100% drafted by and approved by…
NEW: GOP Sen. Mike Rounds say that Rubio called him and several other senators today on the 28-point Ukraine peace plan and "made it very clear to us we are the recipients of a proposal delivered" "It is not our recommendation, it is not our peace plan."
Nascent transcription quantification with scFLUENT-seq nature.com/articles/s4157… (read free: rdcu.be/ePaym)
Nucleus is a company that prioritizes marketing over science. In addition, Genomic Prediction has filed a federal lawsuit against Nucleus alleging Nucleus of theft of trade secrets and confidential information relating to embryo testing. Read this thread/blog post for details.
I've just written a new post raising a series of concerns about Nucleus Genomics, a company that offers embryo selection services based on polygenic scores for couples undergoing IVF. I was shocked by the degree to which Nucleus's work is obviously plagiarized or simply wrong.
I've just written a new post raising a series of concerns about Nucleus Genomics, a company that offers embryo selection services based on polygenic scores for couples undergoing IVF. I was shocked by the degree to which Nucleus's work is obviously plagiarized or simply wrong.
Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues | Nature Communications nature.com/articles/s4146…
This recently remodeled 2-family home, first built in 1850, sits on just a 2,613sf lot just steps from Downtown Salem. Modern zoning would require; 🚫15,000sf lot 🚫100’ frontage 🚫35% max lot coverage 🚫15’ front setback 🚫100’ min lot width 📍Salem, MA
Pathogenic variants in key cancer susceptibility genes were detected in 5% of US adults in the All of Us study, exceeding prior estimates and highlighting race-based differences in prevalence. ja.ma/3K2AU3I
exclusive: Richard Pazdur, just tapped by Trump administration to be FDA's top drug regulator, has privately warned that some of the agency's new initiatives could be illegal and dangerous. w @rachel_roubein washingtonpost.com/health/2025/11…
I've had a missile blow up next to my airplane, been shot at dozens of times by anti-aircraft fire, and launched into orbit — all for my country. I never thought I'd see a President call for my execution. Trump doesn’t understand the Constitution, and we're all less safe for it.
When your dog hears a bag of treats being opened…
This features the truly wild story of how hepatitis C spread to >10% of the Egyptian population in the 1960s:
Did you know >90% of people treated for HIV take an antiretroviral developed by one man, Raymond Schinazi? Read about how schistosomiasis, poorly sterilised needles and Hepatitis C lead to this fact on @DrSamuelBHume's substack open.substack.com/pub/breakinggr…
No single person, especially someone with zero expertise, should be able to just change the CDC website on a whim. The fact that federal health and science pages are no longer trustable is a catastrophe for public health and democracy. nytimes.com/2025/11/21/us/…
Hot off the press! Our latest paper led by @fernpizza , understanding how plasmids evolve inside individual cells. These small pieces of self-replicating DNA live inside bacteria and can transfer antibiotic resistance genes, but they also compete with one another to replicate. 1/
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature…
As a film critic, Leonard Maltin is a good sport about bad takes. He gave Gremlins 1 a bad review so he let them kill him in 2. And when MST3K clowned him for giving Laserblast a good review, he guest starred later to get revenge. Most critics can dish it out but can't take it.
You look up “film criticism” in the dictionary and you get this photo
What's the best exposition you've seen of attention-based sequence transformation, why you can generate all of Q/K/V from the input features, how Q/K end up differing, why the transformer blocks stack to gain expressiveness, &c Feel like I did a bad job with all that
Did the last class of our short Bio x ML class today as a whiteboard progression from Markov -> logistic regression LMs -> dense NNs -> {CNNs, RNNs} for seqs & ended on attention/transformers. Felt like everyone was following well until I got to softmax(Q @ K.T/sqrt(d)) @ V
Reposting my comment from a groupchat; thought the conversation was interesting so sharing here: It used to be that you could get patents for “antibody that hits X”. These days you can only get a patent on “antibody with sequence Y that hits target X”. This is much easier to…
Today we’re thrilled to announce JAM-2 — the first AI model capable of generating drug-quality antibodies straight from the computer, with industry-leading success rates. > Drug-like affinities: Picomolar to single-digit nanomolar antibody binders for half of 26 targets while…
Hey @Delta ! wrt to DL866 Atlanta-Jackson Text I received says gate B20 App says gate C30 Will I get a third answer on a monitor?
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