PREDiCT - Models
@PREDiCT_Models
Uniting preclinical, translational and discovery scientists. Tweeting about innovations in applications of models in R&D. Discover the upcoming PREDiCT events.
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Visit us @PREDiCT_Models Summit in Boston this week and learn how StemoniX products are being used by some of our collaborators! We hope to see you there. Contact us at [email protected] to set up a meeting!
Excellent work from Mathew Garnett's @sangerinstitute group in oesophagal adenocarcinoma organoid cultures to study clonal evolution and precision therapeutics nature.com/articles/s4146… #cancerresearch #drugdiscovery #organoid #organoids #3dtissue #3dmodel #microphysiological
nature.com
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for...
Nature Communications - Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids...
Utilizing 3D organoid culture to predict the metastatic potential of primary prostate cancer - functional assays for patients @PCF_Science @soulehoward1 @UrologySBUR @gr8straj @DrChoueiri @kat_morel @CFCE_DanaFarber
Really interesting work using chip-based 3D models. Given the lack of predictive #models, and only 2 approved symptomatic treatments for idiopathic #pulmonaryfibrosis, clearly, this holds a lot of promise in advancing future therapies nature.com/articles/s4146…
Love seeing all the great research outcomes from organ-on-a-chip projects: here is a recent publication from the University of Buffalo. Dr. Zhao and team simulate pulmonary fibrosis with their lung-on-a-chip system for drug testing. pjj52.app.goo.gl/Km3pl8O89uwIWO…
Fascinating work from @wakeforest. Researchers developed a #3D #organoid model recapitulating the BBB and mimicking normal human anatomy with huge implications for #stroke research nature.com/articles/s4159…
A fascinating presentation from @dangville on the development a new #3Dmodel done in collaboration with @HemoShear for the study of #pancreatic #cancer and #NSCLC. Great to see the novel incorporation of tumor hemodynamics and biological transport #3DOncology18
"A model is a lie that helps you see the truth - the goal with 3D is to minimise that lie" Asellus CEO Brett Hall & @MitraBiotech's Mark Paris explore how 3D Models are revealing molecular and phenotypic insights over 2D models. #3DOncology18
Its been a fascinating morning at #3doncology concluded by the @scrippsresearch Tim Spicer on the use of #3D #spheroids models in discovery. Was amazing to not only see the progress of these platforms in automated ultra HTP formats but thier power over 2D models
Great presentation from @GSK's Jason Ekert exploring some of the scaling and automation challenges for #3D #tumor #spheroids. Was fascinating to see how they've informed their emerging bispecific compounds.
Researchers at Houston Methodist have published data on their "4D" model to show the growth of primary tumours, the formation of CTCs and formation of metastatic lesions linkinghub.elsevier.com/retrieve/pii/S…
Jarno Drost and @HansClevers review #tumor #organoids and their utility as an alternative model for #cancerresearch in this @NatureRevCancer paper nature.com/articles/s4156…
nature.com
Organoids in cancer research
Nature Reviews Cancer - In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research...
New precision #cancer #model combining #CRISPR & #RCASTVA delivery opens doors to personalized cancer treatment by mimicing the genetic complexity of cancer @NatureComms #tumormodel #preclinical #canceresearch #ResearchHighlight #PrecisionMedicine nature.com/articles/s4146…
nature.com
Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
Nature Communications - Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with...
The furture of cellular generation, phenotyping and disease modelling?? #CRISPR derived #organoids
Happy 5th Birthday to Sanger's cell makers! Their expertise in #stemcells, #organoids and #CRISPR powers our large-scale projects into health and disease bit.ly/2HErTwd
"The ML models that are developed will then help guide subsequent experiments, providing a tight, closed loop integration of in silico and in vitro methods (an insitro paradigm).” @JohnCendpts - endpts.com/out-to-rethink…
endpoints.news
Out to ‘rethink the drug design process,’ AI star Daphne Koller is creating a new machine learning...
Daphne Koller has been busy. Just two months since the high profile AI expert exited Google’s anti-aging biotech Calico Labs, where she was chief computing officer, Koller has gathered a ...
Scientists from @wyssinstitute, @JanssenUS & @emulatebio publish results showing the translational potential #organonchip to better predict thrombotic side effects of drug candidates. ascpt.onlinelibrary.wiley.com/doi/abs/10.100…
BASF signs 3D bioprinting cosmetics deal with Poietis 3dprintingindustry.com/news/basf-sign…
3dprintingindustry.com
BASF signs 3D bioprinting cosmetics deal with Poietis
Since 2015, French biotechnology company Poietis has been co-developing its 3D laser-assisted bioprinting technology to fabricate skin models. Now BASF, the largest chemicals producer in the world, wi
It’s now possible to 3D-print an exact copy of a patient’s tumor, right down to its microenvironment and the capillaries that supply blood to it. New from JAX's @Derya_ and @PSUESM's Ozbolat: jax.org/news-and-insig…
A fascinating article showing the power of patient-derived #ipsc & #organoids for disease modelling. #kidneydisease #3dcellculture #3dmodels cell.com/ajhg/fulltext/…
we could link diet, gut bacteria and cancer; medicalxpress.com/news/2017-01-t…
Highlighting the growing role and features of the #TiME which relate to the likelihood of response to #immunotherapeutics go.nature.com/2jlWi41
nature.com
Understanding the tumor immune microenvironment (TIME) for effective therapy
Nature Medicine - The tumor immune microenvironment influences tumor progression and response to immunotherapy; its further characterization will improve therapeutic outcome.
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