Parallel Squared Technology Institute (PTI)
@ParallelSqTech
PTI is a nonprofit focused research organization scaling proteomic technologies to explore proteome biology. A member of the @SchmidtFutures & @Convergent_FROs.
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And they're hiring: jobs.lever.co/convergentrese…
Combining this time domain multiplexing with mass domain multiplexing (plexDIA), we demonstrated combinatorial scaling of throughput. You can read about it biorxiv.org/content/10.110… or hear Jason describe it at PTI's Research Fest: youtu.be/2rLBk4IaZpk?si…
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YouTube
Increasing Mass spectrometry throughput using time encoded sample...
𝐶𝑜𝑚𝑏𝑖𝑛𝑎𝑡𝑜𝑟𝑖𝑎𝑙 scaling may unlock a new level of throughput. This is enabling a long-awaited experiment ! Our team, led by Jason Derks, enabled combinatorial-scaling of mass spec proteomics throughput by developing multiplexing in the time domain, timePlex. 1/n
Mahlon Collins is leading our discoveries in profiling the proteome of single neurons from Alzheimer's disease patients. He presents this research journey in a talk, "Discovering Alzheimer's disease protein dysfunctions with high throughput proteomics". youtu.be/UD8uSIfg7WY
The big picture: Tracing the arc of conceptual milestones in life sciences over the past century, centered around major discoveries driven by evolving technologies. We are excited about the progress & the research enabled by tech from @ParallelSqTech. youtu.be/SrzoLGBVTsY?si…
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Proteomics: The arc of progress in life sciences | Research Fest by...
A thoughtful highlight of our results on alternate RNA decoding: Highlight: science.org/content/blog-p… Preprint: biorxiv.org/content/10.110…
This community is building foundational capabilities for technological progress. Its nonprofit initiatives allow broadly sharing these capabilities. I am happy to support this mission 🚀
We opened a new Head of Development position to join PTI's mission of creating a sustainable and scalable model for non-profit research. We would love to hear from you if you are the right fit for our team! jobs.lever.co/convergentrese…
And, we are back with another presentation from this year's Research Fest. PTI's Senior Computational Scientist, Kevin McDonnell, talks about developing joint modeling (aka JMod) of mass spectra for empowering multiplexed DIA proteomics. youtube.com/watch?v=plK4TC…
Throwback Thursday continues with a presentation by Maddy Yeh and Mark Adamo from Research Fest: "Tags for improving peptide sequencing and throughput in sensitive proteomics". Watch on YouTube: youtube.com/watch?v=jA2I9x…
Throwback Thursday continues with a presentation by Maddy Yeh and Mark Adamo: "Tags for improving peptide sequencing and throughput in sensitive proteomics" from Research Fest. Watch on YouTube: youtube.com/watch?v=jA2I9x…
youtube.com
YouTube
Tags for improving peptide sequencing and throughput in sensitive...
The counting statistics for single-cell MS support accurate estimates of protein abundance in single cells, which is essential for quantitative analysis. Further, measuring and modeling protein degradation is key to biological interpretations. pubs.acs.org/doi/10.1021/ac…
Earlier this year, @ParallelSqTech hosted a research fest. We began with a broad perspective: ◾️ A century of remarkable progress! Proteomics drove conceptual discoveries and medical treatments. Listen to what's next! Proteomics: The arc of progress youtu.be/Sc2QLXb84XI?si…
It's good to look back and see how far we have come since Research Fest took place almost six months ago. Over the next few weeks, we will post some throwback videos from the presentations. Let's start with opening remarks by PTI's Director, @slavov_n: youtu.be/Sc2QLXb84XI
youtube.com
YouTube
Proteomics: The arc of progress | Nikolai Slavov
Our large scale measurements of protein functions and conformations can help realize the potential of AI. When developing AI models, we emphasize careful validation & rigorous benchmarking.
In this article, I shared my perspective on AI. AI excels at supervised learning, and well annotated datasets can help unlock new AI capabilities. 🔗 nature.com/articles/s4225… OA 🔗 rdcu.be/eI4JW
Interpreting single-cell measurements is a challenging and promising frontier ! Solid interpretations begin with the experimental design and considerations about the information that the measurements can provide.
mRNA-mRNA correlations across the single cells from a tissue are rarely interpreted. They differ from the corresponding protein-protein correlations? 𝐖𝐡𝐲 ❓ biorxiv.org/content/10.110… 🧵
𝐏𝐫𝐨𝐭𝐞𝐚𝐬𝐨𝐦𝐞𝐬 𝐩𝐥𝐚𝐲 𝐤𝐞𝐲 𝐫𝐨𝐥𝐞𝐬 𝐢𝐧 𝐧𝐞𝐮𝐫𝐨𝐝𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧 Neuronal inflammation induces PSMB8 Integrating PSMB8 into neuronal proteasomes reduces their activity This causes PFKFB3 accumulation, a metabolic switch, and ferroptosis 🧵
I am looking forward to ICSB next week. I will present: 1⃣ New technology from @ParallelSqTech: parallelsq.org/blog/proteomic… 2⃣ New biology from @slavovLab: biorxiv.org/content/10.110…
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Potrebbero piacerti
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Slavov Laboratory
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