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The Reik Lab are excited to join Altos Labs - whose launch was announced today prn.to/3FBwEzH - to work on cellular rejuvenation programming, whilst continuing to work with our wonderful community @BabrahamInst
Curious about the seemingly contradictory functions of m6A in R-loops? Check out this comment by @a_abakir & @AlexeyRuzov out in @NatureGenet where they propose a new model for a dual function of m6A in R-loop regulation. nature.com/articles/s4158…
Check out Wolf speaking at the recent @codexworld Top 50 Innovators event! 🧪 youtu.be/KPzCXAmSeR8?si… #T50 #CodexTalks
youtube.com
YouTube
Can cells and organs be rejuvenated and can this restore cell health?...
The product of a large and exciting international collaboration! Our study investigating the consequences of the endocrine disruptors DDT/ DDE on the sperm epigenome of Greenlandic Inuit and South African VhaVenda men is finally out. ehp.niehs.nih.gov/doi/10.1289/EH…
Need a podcast for your commute or for cell culture? 🎧Check out Wolf, @METorresPadilla and @Boyan84 discussing epigenetic regulation in development, ageing and rejuvenation as part of the @PioneerCampus Podcast! 👇
Welcome to the newest episode of @PioneerCampus #Podcast @METorresPadilla @Boyan84 from @HelmholtzMunich discuss with Wolf Reik @altos_labs Cambridge #Epigenetics from organ #development to #regenerative #medicine podcasts.apple.com/de/podcast/hel…
Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below! cell.com/cell-genomics/…
My main PhD work is now out as a preprint 👇
Welcome to the newest episode of @PioneerCampus #Podcast @METorresPadilla @Boyan84 from @HelmholtzMunich discuss with Wolf Reik @altos_labs Cambridge #Epigenetics from organ #development to #regenerative #medicine podcasts.apple.com/de/podcast/hel…
In our latest publication, we recapitulated features of early human #development and characterised the #epigenetic landscape of naive and primed hPSCs in vitro. We found that X chromosome erosion is reversed by resetting and subsequent hPSCs capacitation: science.org/doi/full/10.11…
Excited for the pre-print of our latest work to go public! In this study, we discovered that DNA damage tolerance is required for mammalian primordial germ cell DNA demethylation and development biorxiv.org/content/10.110… Fantastic collaboration with @ReikLab @HGLeitch 1/9
Please RT! We have a position for a Research Associate/Senior Research Associate to work on chromatin mechanics in cellular ageing and rejuvenation. @ReikLab; @altos_labs boards.greenhouse.io/altoslabs/jobs…
Job alert 🚨 We're looking for a Research Associate/Senior Research Associate to work with us on chromatin mechanics in the context of cellular ageing and rejuvenation. More details here 👇 boards.greenhouse.io/altoslabs/jobs…
Happy to share our News and Views article on a new enzymatic 5mC sequencing method by @KohliLab and colleagues out in @nchembio. @ReikLab; @altos nature.com/articles/s4158… and the original article: nature.com/articles/s4158…
nature.com
Direct methylation sequencing
Nature Chemical Biology - Sodium bisulfite is widely used in methylation sequencing, yet it degrades DNA, and on its own, it does not discriminate methylated cytosine from its oxidized derivative,...
Lab members are having a great time at #ISSCR2023, despite getting a bit soggy in an unexpected storm! @AliceSantam @ikafetzo @BrendanTerry8
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