Subhojit Roy, MD, PhD
@Roy_Lab_Thinks
Science. Music. Sometimes funny. https://www.youtube.com/channel/UCd_bJwirwOnBeTb8K-t0xyA
قد يعجبك
Massive 10+ year effort in lab spearheaded by @leonardoaparrar and Kayal (secret account 🤔). Unreal cover by @EmmaVIDALL that says it all.
2023's final issue is out! cell.com/neuron/current Cover story is from @Roy_Lab_Thinks's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here cell.com/neuron/fulltex…
...but as G. Costanza would say: is this "Significant Shrinkage"?
Neurons transmit signals through synaptic vesicle release, but the nanoscale dynamics of this process have been unclear. In a new Science study, researchers report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ and propose a unified…
Incredible by @OdedRechavi ... an AI thingy-bop that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: qedscience.com
"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones" nature.com/articles/d4158…
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @DrNeuroChic authors.elsevier.com/a/1lxn85FFzL...
Thank you John Sayer @johnasayer for sharing your experience of fee-free #OA publishing in @J_Cell_Sci via our #ReadAndPublish agreement with @Uni_Newcastle @uonlib Read John’s paper bit.ly/4q8NMFC Is your institution participating? bit.ly/3O7BxGi
4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC. universityofcalifornia.edu/news/uc-wins-5…
I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14: sfn.sg/sfn-sg-annual-…
Honestly if I was a non human primate, I'm not sure I'd appreciate a human just sitting and staring at me all day. #justsa
I went to #Chile 25 years ago - when Internet wasn't a thing - and this is all I needed to know. It went just fine.
“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world" theguardian.com/tv-and-radio/2…
"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes. bbc.com/news/articles/…
"But the foibles and embellishments that make up his story have no place in modern cricket - rubber snakes, mobile phones, firecrackers et al - all of which would today attract ICC demerit points, rather than foster sense of enjoying the stage together" espncricinfo.com/story/dickie-b…
Slowly getting ready to finally submit this paper. Would love feedback. In essence, we mapped and tracked EV transfer of a-synuclein single molecules from neurons to neurons. @Roy_Lab_Thinks @christlet biorxiv.org/content/10.110…
Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! nature.com/articles/s4159…
Our new preprint is up! This is the main postdoc work of Theresa Wiesner, focusing on exocytosis along the axon shaft and its regulation by the submembrane actin-spectrin scaffold: biorxiv.org/content/10.110… Read the thread below for a summary of our findings 🧵1/11
“I am not that interested in dinosaurs for the sake of dinosaurs or even interested in when they populated the planet...I’m interested in creating questions in science that someone hasn’t thought to answer yet” nytimes.com/2025/09/13/sci…
Meanwhile. Ants. ksl.com/article/513746…
"...being careful with language. Always put yourself in the shoes of the author. Start by writing something positive, and then lay out what is not so good about the work in a totally unemotional and logical way” nature.com/articles/d4158…
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