The Rullo Lab
@RulloLab
Student-run Twitter for the Rullo Lab @McMasterU, located in the Michael DeGroote Centre for Learning and Discovery (MDCL)🧪 Find us at: http://rullolab.com
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Very excited to share our group's latest research, published in @NatureComms, titled 'Mimicry of molecular glues using dual covalent chimeras'! @LabRullo Check out the full publication here: nature.com/articles/s4146…
nature.com
Mimicry of molecular glues using dual covalent chimeras
Nature Communications - The authors report the development of dual covalent proximity inducing molecules capable of selectively cross-linking two non-interacting proteins. Through the selective...
Incredibly proud of @RulloLab members Karolina Krygier, Tomas Frankovich and Anjalee Wijetunge for brilliant presentations at @qomsboc 2024!
@LabRullo was cited in an independent blog on @ScienceMagazine website written by Derek Lowe titled “Induced Proximity in the Lab and in the Clinic”. He is cited at the 4th link. 🔗science.org/content/blog-p… Congratulations! 👏🥳 @RulloLab @machealthsci @MacDeptMed
Covalent bispecific molecules to engage tumor-immune proximity @LabRullo doi.org/10.1016/j.omto…
Brilliant contribution by @DASpiegel256 and co workers to induced proximity
Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells | Journal of the American Chemical Society @Yale @YaleChem #Targeted #Degradation #Transcytosis #BrainCells #Proteins #Extracellular pubs.acs.org/doi/10.1021/ja…
Congratulations to Sandra for being named CDCR’s trainee of the month!
Beautiful oxaziridine based oxidative approach to tryptophan labeling ! @christhechang and toste labs nature.com/articles/s4158…
Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase dlvr.it/T4YBjx
A beautifully written comprehensive review on the use of proximity induced chemistry to generate novel protein therapeutics by @Han_Xiao2016 cell.com/cell-chemical-…
Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and Membrane Proteins | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and...
Protein degradation is a highly regulated cellular process crucial to enable the high dynamic range of the response to external and internal stimuli and to balance protein biosynthesis to maintain...
Excited to present our work in covalent bifunctionals, for inducing cell-cell proximity in immunology ! #Covalent #proximity trccc.org/annual-meeting
trccc.org
Annual Meeting | TRCCC
Annual Meeting | TRCCC
Excited to return to beautiful Boston this Tuesday and see great colleagues working in covalent drug development and proximity inducing molecules! covalent-drug-discovery.com/whats-on/speak…
Join us tomorrow for our Work in Progress Seminar!
Check out our newest publication featuring @BenjaminLake15 ! Congratulations!
Happy to share our most recent contribution coupling covalency with carbohydrate binding for immune proximity induction. pubs.acs.org/doi/full/10.10…
Join us tomorrow for WIP, featuring Annika Yardy from the Larche lab and Danielle Libera from the @jfekoenig @Jordana_Lab!
A must read
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues dlvr.it/SxGnd3
Beautiful review @Han_Xiao2016 ! pdf.sciencedirectassets.com/313924/AIP/1-s…
Congratulations to Eden for an amazing Ph.D. comprehensive exam! Eden passed with distinction, and the entire Rullo lab is extremely proud. Well-deserved 🥳
Congratulations Sissi on a strong Master’s Defence! Wishing you all the best in your future endeavours 🎉🥳👏
Brilliant covalent chimeric technology developed by @ChoudharyLab to chemically modulate protein phosphorylation pubs.acs.org/doi/10.1021/ac…
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