Avtar Singh
@avtar00_singh
principal scientist @genentech | genomics | microscopy | biophysics
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Excited to share our manuscript describing #OpticalPooledScreens - a new technology that enables large-scale image-based screens in mammalian cells! @CellCellPress @broadinstitute #CRISPR #microscopy
In a study published today in @CellCellPress, scientists at the Broad and @MIT present a new image-based genetic screening method that helps researchers identify key regulators of inflammation. broad.io/BlaineyCell
Exciting internship opportunity with Bo Li to develop deep learning methods for OPS data - please apply/share!
Are you interested in applying deep learning skills to cutting-edge high-content perturbation screening? Apply for this internship position from my team! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
Our image-based genome-wide screen identifying new regulators of STING localization is now online at @CellSystemsCP! authors.elsevier.com/c/1kEhc8YyDfql…
Happy to share this manuscript as a goodbye to the Broad. This would have not been possible without @beccajcarlson and input from @BingxuL. biorxiv.org/content/10.110… We used Optical Pooled CRISPR Screens to classify genes regulating STING trafficking A 🧵
Super cool tech from @MohamadNajia @jacobborrajo Anna Le and the @BlaineyLab for cellular self-reporting! Congrats to the team!
Excited to share how @jacobborrajo Anna Le and I are enabling the future of profiling dynamic cellular processes! We built a synthetic RNA export pathway for cells to "self-report" their transcriptional states in real-time. Big thanks to the entire team! biorxiv.org/content/10.110…
We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis, details and apply here: broadinstitute.avature.net/en_US/careers/…
Been on a videos hiatus lately, in part bc we've been working hard to finish up our paper: We present a method called SDR-seq for targeted, simultaneous genotyping & expression measurement in single cells!
I am excited to share a part of my postdoctoral work that came out today in @Nature. We developed a single-cell nascent RNA sequencing method (scGRO-seq) that, among other applications, can help generate enhancer-gene maps. 🧵1/13 nature.com/articles/s4158…
Published (and open access)! Super excited to share the final version of our manuscript describing an enhanced mutagenic base editing platform for use in functional genomic screening. See original tweetorial for more details. cell.com/cell-reports/f…
Now online! New-preprint from the always-brilliant Kristel Dorighi with essential contributions from many others at @genentech; enhanced Cas9 base editing (BE) for drug resistance variant discovery. biorxiv.org/content/10.110…
Rich phenotypic profiling of genome-scale libraries by combining optical pooled screens with Cell Painting! Check out this wonderful Tweetorial by @JamesTneal and our linked preprint!
Now online! New-preprint from the always-brilliant Kristel Dorighi with essential contributions from many others at @genentech; enhanced Cas9 base editing (BE) for drug resistance variant discovery. biorxiv.org/content/10.110…
Wow, STING is a proton channel! 🤩 This was the working title of our paper for quite awhile (emoji definitely included), really capturing our excitement at this discovery!
So excited to finally share one of the most fun and exciting projects from my PhD! Here, @beccajcarlson and I show that STING, a key player in the immune system, is a proton channel. Paper: lnkd.in/eQ6TXhvr MIT News Story: lnkd.in/eXExmjta
A chance to postdoc in human genetics at Genentech. Our passion: using HG to help us make safe & effective drugs. Your task: help us figure the overlap bw the genetics of disease risk & progression, & how best to apply genetics to clinical trial design careers.gene.com/us/en/job/GENE…
Incredible opportunity to develop and apply cutting-edge tools for spatial profiling and lineage analysis at Genentech with the ultra-talented and creative Eric Lubeck! Don't hesitate to reach out if you have any questions. And please share! tinyurl.com/SpatialBio
Exciting news - I've joined Genentech to lead the Advanced Cell Engineering Hub, and we are growing our team! We are seeking a Scientist 3 to advance next-generation methodologies and applications in iPSCs and primary cell models. Please share and apply! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
Summer internship opportunity at Genentech! Come join me in identifying cellular circuits in aging & improving technologies for cellular reprogramming. Undergrads, MS & PhD students are eligible. careers.gene.com/us/en/job/2023…
Exciting summer internship for PhD students @genentech! Develop new strategies for image based screening with an outstanding mentor - reach out to @anqiz91 for more info!
I am hiring a 2023 summer intern at Genentech on microscopy-based image processing and statistical analysis. If you happen to be or know anyone who is interested and has relevant experience, please reach out or spread the word! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
careers.gene.com
Careers at Genentech
The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.
Dear students and post-docs. There is a land where we will pay you for your time and you can do cool science that helps people. Come. Apply. Make cells do interesting things with us. Push back the frontiers of what we can do with bits of regulatory DNA. roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
I’m hiring a computational scientist 3 at Genentech to analyze cutting-edge single-cell genomics and high-throughput screening data in an extremely collaborative environment focused on finding cures for disease. Please reach out to learn more. careers.gene.com/us/en/job/GENE…
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