Charlie Buchanan
@charliebuchanan
🧪 DPhil Physical and Theoretical Chemistry in Baldwin Group @ University of Oxford 🚣🏻♂️ Boat Race Blue 2019 He/him
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An integrative characterisation of proline cis and trans conformers in a disordered peptide biorxiv.org/cgi/content/sh… #biorxiv_biophys
Protein fractals are a thing! BUT their beguiling looks can be deceiving - these have the hallmarks of being accidentally (and neutrally) evolved... Such interesting and beautiful work - congratulations @SendkerFL and the whole team!!
Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here nature.com/articles/s4158… Or just stick around 🧵
If there are two things I love they are protein dynamics and NMR - such a ferocious study - really beautiful and well done to the whole team! @DFlemmingHansen @bhu_vaibhav @SiemonsLucas
In our latest paper @PNASNews a tour-de-force analysis of #NMR CPMG data by @bhu_vaibhav shows, for mutants of HDAC8, that changes in enzymatic activity and inhibitor potency are all captured in the structural dynamics. @UCLLifeSciences @SiemonsLucas pnas.org/doi/10.1073/pn…
In our latest paper @PNASNews a tour-de-force analysis of #NMR CPMG data by @bhu_vaibhav shows, for mutants of HDAC8, that changes in enzymatic activity and inhibitor potency are all captured in the structural dynamics. @UCLLifeSciences @SiemonsLucas pnas.org/doi/10.1073/pn…
Our #NMRchat DNNs are now able to transform crowded HSQC spectra of large proteins (<350 kDa) into spectra akin to Methyl-TROSY (methyl-TROSY-fication). Read the full story on bioRxiv: doi.org/10.1101/2023.0… @EPSRC #DeepLearning @UCLLifeSciences @gogulan_k @bhu_vaibhav
We used #nativeMS electrospray ion beam deposition (ESIBD) to make samples for #cryoEM: mass-filtered, soft-landing deposition, cold substrate, in-situ ice growth, clean+cold transfer...we find... @ESIBDLab with many colleagues @OxfordChemistry @KavliOxford #structuralbiology
Cryo-EM of soft-landed β-galactosidase: Gas-phase and native structures are remarkably similar biorxiv.org/cgi/content/sh… #bioRxiv
If you’re gonna see Queen Beyoncé you must know the lyrics to Heated.
Certain structures (e.g. some carbohydrates) are notoriously immunorecessive. Check out our latest preprint describing a germline ‘reach-through’ model for glycan-specific B cell activation. biorxiv.org/content/10.110… (1/4)
BT made £1.3bn, gave £750m to shareholders and the CEO got £3.5m. We have members using foodbanks. Today BT announced £400m profit for 1/4 year. Tomorrow our members strike for the first time since 1987 and have been subjected to extreme intimidation. RT if you back them.
Royal Mail Group profits £758m Shareholder payout £400m Paying TWO CEOs £2m + Imposed 2% on loyal postal workers who kept the country connected during the pandemic. They’re using Swiss banks whilst our members use foodbanks. Ballot result Tuesday. RT if you back us.
@charliebuchanan’s (and other colleagues/collaborators) work being described by Ben Davis. @KavliOxford
Pembroke Chemistry Tutors, Prof Andrew Baldwin & Prof Ben Davis have collaborated with DPhil student @charliebuchanan on a new research paper which has been published in @ScienceMagazine! Read more here: bit.ly/3zZIPam
A study of #SARSCoV2 finds evidence for a sialoside binding site in the early-pandemic B-origin lineage. Binding is lost in later, more transmissible variants, consistent with hypotheses that such sites can vary and may contribute to fitness. #glycotime fcld.ly/dockjdx
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