Gokhan Cucun
@gkhnccn
Postdoctoral Researcher at Karolinska Institutet, Neurobiologist http://gcucun.bsky.social
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Perspectives in @ScieMagazine after our Asilomar conferences on neural #organoids and #assembloids science.org/content/articl…
science.org
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
Our latest work is out today in @ScienceMagazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids…
We have developed DELIVR, a user-friendly deep-learning pipeline for automatically detecting and analyzing cells from whole-brain images to map neuronal activity via cFOS. DELIVR uses virtual reality to substantially accelerate the generation of training data and is accessible to…
📣 Symposium 2050 at the University of Zurich Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts. Free and open to all! More info/register: ema.uzh.ch/RTTHF
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress: nature.com/articles/s4159…
Today in @Nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇
We’re living through pretty unusual times, but we’re excited to share good news! Our CRISPRa-programmed #embryo model paper is out! Thanks to our amazing group @glodewijk_sci @sayakakozuki and collaborators. I hope the community finds this model useful for new discoveries #CRISPR
Online Now! Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming dlvr.it/TJfDpC #stemcells
A great school to learn the finest all optical experiments from the @EmilianiLab and world experts on in vivo single cell manipulation at ms resolution, voltage population imaging and more : sign up now to secure your spot!
We’re thrilled to announce that registration is now open for the 6th edition (on March 2025) of the Paris School on All-Optical Neuronal Circuits Control with Optogeentics and Multiphoton Microscopy! Join us and explore the latest breakthroughs with an outstanding lineup of…
I really enjoyed writing this Perspective for the special issue on Neuroscience. It's an exciting time to study the human brain! Unraveling mechanisms of human brain evolution: Cell cell.com/cell/fulltext/…
Our newest work is online now in Neuron @NeuroCellPress showing the generation of diencephaluc #organoids, assembly to form cortico-thalamic #assembloids and their application to discover defects following loss of function and gain of function mutations in CACNA1G, which are…
Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. nature.com/articles/s4158…
We're excited to share our new study on the role of the ABCA7 gene in brain resilience against #Alzheimer’s. Published in @CellGenomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating #neuropeptide Y (NPY), a key molecule for brain communication and…
Save the date 7-8/10/2024 : GDRImabio will co-organize with @Fr_BioImaging a workshop on "High Resolution 3D Microscopy in Biology: Development & Applications", happy to welcome @JungmannLab @Sciezgin Sophie Brasselet @Gaelle_Recher and Virgile Viasnoff, call for abstract soon !
Update - Motor school following Brain prize @Cajal_Training @bdxneuroschool Apply by **July 22** for in vivo mini projects on neuropixels, behavior in humans, all optical experiments for connectivity mapping in brainstem, test how many command neurons elicit motor actions & more!
Hola MOTOR afficionados intrigued by BEHAVIOR!! Sign up by *July 3rd* @BrainPrize @Cajal_Training @bdxneuroschool featuring @KiehnLab S. Arber @RuneWBerg to learn⚡️Optogenetics, 🫏 tracking, CRISPR 🧬editing, Neuropixel magic, Population imaging & 🧠 Machine interface in humans!
Online now: Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions dlvr.it/T7ZBJM
cell.com
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome...
Koppers et al. use nanoscale resolution imaging to show that the axonal endoplasmic reticulum (ER) interacts with ribosomes to support ER-dependent local protein synthesis and identify P180/RRBP1 as...
Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. nature.com/articles/s4159… by @Dorie00 @Rami96614090 @moritz_negwer
Really excited to announce our international #WNT meeting 2024 in Heidelberg (Sept. 25-27). A great opportunity to meet amazing colleagues, discuss outstanding science, and think about the future of the field. Organised by @sfb1324 Please register here: sfb1324.de/wnt2024/
The Plasticity Team is making it happen! For those who strive to transcend disciplinary boundaries, we welcome you to our interdisciplinary symposium on #Plasticity, powered by the @CentreUnusual. More on #identity, #time and #mind translationalneuroscience.nl/news/the-shape…
Doing research abroad comes with its own set of social, emotional, and bureaucratic challenges. In our latest ecrLife post, @Izzie_Hb, @arorankita, and @RuchikaBajaj9 talk about the problems faced by our international colleagues and how to help them thrive tinyurl.com/mtpy36my
Today we are sharing our most complex #assembloid to date: a 4-part model of the human ascending neural somatosensory pathway generated by functionally integrating stem cell-derived cerebral cortical, thalamic, spinal and sensory #organoids. Check out the @biorxivpreprint and…
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