Jacopo Pasqualini
@jcppsqln
Solvitur ambulando / Studying proteins at Schwede group @biozentrum, Basel (CH) / physics PhD @LIPh_Lab, Padova (IT) / Apprentice Philosopher
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📢📢📢 PAPER ALERT📢📢📢 I'm glad to share with y'all my first peer-reviewed paper! I, @SamirSuweis, and our collaborators tried to answer the question: what makes healthy and diseased gut microbiomes different? A thread on our stat.phys. answer 🧵1/n journals.plos.org/ploscompbiol/a…
Generative genomics takes off. Next steps will be greater and greater
Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
all models want to do is talk to each other. alphafold wants to talk to borzoi. borzoi wants to talk to evo. evo wants to talk to gemini 2.5 pro. gemini 2.5 pro wants to talk to bioemu. they do NOT want to talk to a human. they will if they are forced to but will not enjoy it
(1/11) Genomics databases, like the SRA, host tons of data. But data access is challenging, driven largely by tooling. Below is a brief history on genomics data access. 🧵
Extracting @NCBI SRA files with fasterq-dump can require 17x the size of the accession while decompressing. Our new tool xsra extracts sequences at 5x throughput with significantly less disk usage, built-in compression, and optional BINSEQ outputs github.com/arcInstitute/x…
🚀 New research alert! 🚀 Led by @jack_bjo @gnicoletti09 @dbusiello1, our latest work in Physical Review Letters (journals.aps.org/prl/abstract/1…) reveals how excitation-inhibition balance tunes the timescale of information coding in neuronal populations! 🧠🔬
#Balanced excitatory and inhibitory neuron activity is crucial for optimal brain #InformationProcessing, enhancing encoding efficiency and stability, according to recent findings in neuroscience. @physrevlett doi.org/g87h5w phys.org/news/2025-03-o…
phys.org
Optimal brain processing requires balance between excitatory and inhibitory neurons, study suggests
The brain's ability to process information is known to be supported by intricate connections between different neuron populations. A key objective of neuroscience research has been to delineate the...
"Les Houches lectures on Theoretical Ecology: High-dimensional models and extreme events" (by Ada Altieri): arxiv.org/abs/2503.02792 Note: Lectures given at Les Houches Summer School "Theory of Large Deviations and Applications" (July 2024)
Here’s the article: statnews.com/2024/12/12/art…
statnews.com
What I’ve learned — the hard way — about AI in bio
Presenting the five stages of AI grief (techbio’s version), from Tessel Bio's @NTallapragada.
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