Shruthy Suresh (Aggarwal)
@shruthy_suresh
Scientist interested in cancer @igibsocial @cancermetslab Tweets/RT my opinion Bio: https://www.igib.res.in/?q=ShruthySA
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I am thrilled to share this viewpoint essay about my first year as a #cancerresearch PI. Our lab just turned one & this was the perfect opportunity to reminisce on the journey thus far. It has only begun, excited for it all. Grateful to @NatureCancer for inviting me to share this
Viewpoint now ONLINE! @NatureCancer ⭐️'The 2024 generation' 🔗nature.com/articles/s4301… Don't miss this piece where 12 #ECRs who started their #cancerresearch labs in 2024 reflect on the experience so far, including the ups and downs of the journey, and their plans for the future.
Wonderful summary resource from @CancerResearch @ay_zhou et al: The global landscape of cancer cell therapies, clinical trial trends and emerging directions nature.com/articles/d4157… @NatRevDrugDisc
CSIR -IGIB welcomed the Parliamentary Standing Committee on Science and Technology, Environment, Forest and Climate Change today. Members of Parliament interacted with the students and scientists at length. @PMOIndia @DrJitendraSingh @PrinSciAdvOff @BKalitaAssam @krsureshreddy…
Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy. Huge congrats to all authors! nature.com/articles/s4158… nature.com/articles/s4158… #Ferroptosis #FSP1 #CancerResearch
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)
Excited to share our paper on a dramatic case of cancer lineage plasticity: melanoma to rhabdomyosarcoma transformation during ICB. Always fun working w/ Ryan Sullivan, David Liu, Keith Flaherty, Peter Sorger, among others. @MGHCancerCenter @broadinstitute medrxiv.org/content/10.110…
The "Big Bang" of cancer evolution: for colon cancer, evidence that immune evasion occurs very early nature.com/articles/s4158…
Secretome translation shaped by lysosomes and lunapark-marked ER junctions nature.com/articles/s4158…
Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace). doi.org/10.1038/s41588…
Excited to share our new work demonstrating that RAS-ON inhibitors have activity in NRAS mutant melanoma preclinical models and in melanoma patients! @MoffittNews @MelanomaReAlli @CureMelanoma aacrjournals.org/cancerimmunolr…
Phagocytosis: a process that shapes immune responses to engulfed meals bit.ly/49u0xVa
This is what the last five years have been about! Incredibly proud to share our new paper in Nature Genetics: “Transcription Factor Switching Drives Subtype Specific Pancreatic Cancer.” Thank you @JCarrollLab @PancreaticCanUK @CRUK_CI nature.com/articles/s4158…
Excited to see my PhD work out! Here, we find an unexpected epigenetic mechanism that regulates oncogene amplification to promote tyrosine kinase inhibitor resistance in lung adenocarcinoma. Tweetorial below! ⬇️ nature.com/articles/s4159…
.@NatureGenet paper by @BizarMd @columbiacancer Cellular states associated with metastatic organotropism & survival in patients with #PancreaticCancer “pre-existing cellular states within primary tumors appear to guide organ-specific metastatic relapse” nature.com/articles/s4158…
Congratulations to my PhD student Tim Arnoldus @NKI_nl @oncodeinstitute on publishing his discovery today in Nature Genetics! 🎉 Taking a computational approach, Tim found a synthetic lethal target that may impact future treatment of half of all cancers👏nature.com/articles/s4158…
New causal genetic evidence shows it's likely that statins (HMGCR), PCSK9 inhibitors, ezetimibe (NPC1L1), and other cholesterol lowering drugs not only reduce heart disease risk, but also prevent dementia!
Now online! Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance dlvr.it/TNtFrz
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells #immunometabolism science.org/doi/10.1126/sc…
Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy biorxiv.org/content/10.110… #biorxiv_immuno
The molecular basis for signalling between epithelial and mesenchymal cells in pancreatic cancer has now been revealed go.nature.com/3WRHJYs
Researchers in Science have uncovered a surprising role for cholesterol regulation in immune cells. By controlling T cell signaling, the cholesterol transporter protein Aster-A not only shapes immune responses but also influences how the body absorbs fat—protecting mice from…
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