Parker Singleton
@singletonion
dad - senior scientist at http://pennlinc.io - psychedelics and other fun stuff - aspiring urban homesteader - http://sypres.io
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🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧵
On the second anniversary of Roland Griffiths' death, I'm taking the opportunity to reflect on the value of scientific curiosity and the virtue of constant curiosity about life in general that he seemed to me to so consistently embody.
It's been a week since my advisor, colleague, & friend Roland Griffiths passed away. Even though it was expected, his death still came as a shock and I've been trying to find the right words. I wrote this to honor one of his exceptional qualities--his spirit of radical curiosity:
one of the coolest works I've ever had the joy of being a part of! hats off to Parker on this thought-provoking piece.
In the Allostatic Triage Model of Psychopathology (ATP Model), we propose a novel concept: Allostatic Triage: the stress-induced redistribution of energy from CNS networks optimizing long-term outcomes to those supporting short-term survival.
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s4159… #Neuroscience #Psychedelics #BrainImaging
How does energy keep us alive? Our bodies are resistive energetic circuits where electrons flow from food→oxygen in our mitochondria. It's only through energy resistance (éR) - like electrical resistance - that transformation of energy into life is possible. The Energy…
New @ImagingNeurosci from @BrandonTaraku: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression direct.mit.edu/imag/article/d…
Interested in the mechanisms shaping the extraordinary complexity of the connectome? Then check out our new preprint, lead by @_francisnormand with a stellar team showing how geometry constrains connectome architecture: biorxiv.org/content/10.110… Peep the 🧵
"We are not anti-psychedelics; we just want historical accuracy." Psychedelics, Eleusis, and the Invention of Religious Experience liebertpub.com/doi/10.1177/28…
Musical Chess teaches toddlers and big kids with hands-on fun greenvilleonline.com/story/upstatep…
Today is publication day for my book, Shamanism: The Timeless Religion. To celebrate, here are some of my striking clips of shamanic rituals that I came across while working on the book:
Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder jamanetwork.com/journals/jama/…
Is this one of the two or three? academic.oup.com/ijnp/article/2… "Mindset prior to dosing, and spiritual experiences and perceptual shifts during dosing were identified as possible predictors of treatment trajectory [...] while treatment expectations did not influence outcomes."
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" researchsquare.com/article/rs-731…
Claustrum!
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum doi.org/10.1038/s41467…
📣 We’re recruiting 1-2 postdocs to the incredible WBHI team to lead projects mapping brain & behav’l changes across major endocrine transitions—from adolesc to pregnancy to menopause. Expertise in MRI & human subjects necc. Please reach out to [email protected] 🌊
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