awe! received my parcel today. Thanks team @pillar_vc for sending this beautiful gift all the way to the other side of the world

Most of the hate I get is understandable. Wealthy guy doing unusual things for health. Looks weird. Acts weird. Says weird things. Ok. There’s also something else going on. Ultraprocessed foods emerged in the 1970s. Those in adolescence / early adulthood (now 50-64) exposed…
Morning folks. I've uploaded the paper on Pakistan's Power Sector since WAPDAs founding (1958) and how the transition to IPPs almost bankrupted Pakistan papers.ssrn.com/sol3/papers.cf… Many thanks to my colleague Mr. Fazli Hadi and @nadeemhaque @malikafia2021 for their valuable input 1/2
Lot of crypto folks asking me "What happened?"... It's probably time to dust off the Taleb book 'Antifragile'. The amount of Open Interest that has been taken off in one day is unreal. 15B -> 6B on hyperliquid alone, the real total number must be insane! People always want a…

Today, @AsimovPress published an incredible piece from @cogcelia on moving away from animal testing. More specifically, Celia focuses on what we are moving toward and where these non-animal methods will outperform conventional alternatives.

dating as a founder is hard you’re obsessed with what you’re building it consumes every thought, every hour you try to date, but small talk feels foreign you’re wired to build, not to “relax” you don’t want someone to fix it or compete with it you just want someone who…
We've had the biggest supply/cost basis reset basically ever at this $80-120k range. OG whales unloading into new ETF buyers non stop. This means we've reset the cost basis and built a new floor mid bull at $100k. This means few sellers left above here. This means fireworks.
as a former NIH employee during the first trump administration, thousands of NIH employees are still going in to >feed their cells >keep their animals alive >finish the last experiments before publication science doesn't just stop like shutdowns stop. also scientists don't…
قوم پرستی اصل میں ایک ایسا نشہ ہے جو کمزور دماغوں کو یہ یقین دلاتا ہے کہ وہ کسی عظیم چیز کا حصہ ہیں حالانکہ وہ محض ایک دھوکے میں جی رہے ہوتے ہیں.. یہ نفرت نہیں سکھاتی بس دوسروں سے نفرت کرنے کا جواز فراہم کرتی ہے..ہر قوم پرست یہی سمجھتا ہے کہ اس کی زمین اس کی نسل اور اس کا عقیدہ…
It’s time for Science Capital Markets? I spoke to @_JerryLi, DeSci BD at @solana. The bet is clear: give researchers the same tools startups have: liquidity, community, and distribution.
Folks, finally done with the study which I'll put up in a day or two. Meanwhile, I've attached a very brief Summary. Additionally, there are 4 CH's; CH 1-WAPDA-A promise manufactured into a problem; CH 2-IPPs, Private Energy and Public Management-The road to hell is paved 1/2


😱😱 “…there are now 120+ "in vivo CAR-T" companies in China.” 🇨🇳
just back from shanghai / beijing / HK, met several chinese pharma, 10+ biotechs, local VCs - notes / comments from the trip: * what China did to ab's / bispecifics / TCEs, they are about to do (or already have) to genetic medicines * there are now 120+ "in vivo CAR-T"…

I finished my estimate on required compute to make an atomic-resolution virtual cell: 10^38 FLOPs to simulate a human cell for 1 day. We should be able to do this simulation in 2074 using 200 TW of power. 1/3

I became Senior VP at a multi-million dollar company at age 26. My salary was $600k. This was in 2018. How did I do it? It wasn’t hustle culture. No 5:30am wakeups, cold showers, or productivity hacks. What got me there was a relentless focus on impact. Every project I…
I think one of the largest issues in my life currently is that I'm simply never bored. Boredom creates space for doing, a space to develop discipline. It's a vacuum begging to be filled but it's far to easy these days to fill when the world is at my fingertips. I can hop on here…
For now, since I don’t want to have us all buy embryos on some social media marketplace through some AR glasses, I urge us to start a counterculture of love. Biology’s greatest “feature” has never been an eye color, fur texture, or voice tone. The most beautiful “feature” of…
The internet has no rules. Everything you think is "normal" online was made up. The stock market wasn’t supposed to be memes. Currency wasn’t supposed to be jokes. Attention wasn’t supposed to be money. But now it is. Why? Because enough people agreed it should be. Tokens…
Can AI cure disease & make science faster? @pdhsu @JorgeCondeBio and @eriktorenberg discuss (00:45) The Moonshot: Virtual Cells and Human Biology (02:58) Interdisciplinary Collaboration at Arc Institute (05:11) The Role of AI in Biology (10:18) Understanding Virtual Cells…
It is incredible that GLP1s work for reducing cravings with evidence in alcohol use disorder, opioid use disorder, and cannabis use disorder. A little peptide that comes from the proglucagon gene primarily made by pancreatic and gut cells (and to a lesser extent in the brain)…

Ozempic for social media dopamine is humanity's last best hope and I'm only half kidding
Check out our new perspective "Illuminating the universe of enzyme catalysis in the era of artificial intelligence" now out in @CellSystemsCP ! We discuss a vision and path forward for genetically encoding almost all chemistry, powered by new AI tools: authors.elsevier.com/c/1lg4h8YyDfuZ…
One of the most epic framings of human genetics that lives rent-free in my head: "The human population, through explosive growth, has performed a comprehensive saturation mutagenesis experiment on itself. It is now the case that any single base substitution that is compatible…

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