Fitzpatrick Laboratory
@FitzpatrickLab
Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.
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New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM biorxiv.org/content/10.110… Experiments made possible by support from @cziscience #ImagingTheFuture
Structural basis of regulated N-glycosylation at the secretory translocon: nature.com/articles/s4158…
If you only read one of our research group's papers this year - make it: "How small molecules stablize oligomers of a phase-separating disordered protein" biorxiv.org/content/10.110…
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/sc…
Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B - Godrich - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…
Neurons transmit signals through synaptic vesicle release, but the nanoscale dynamics of this process have been unclear. In a new Science study, researchers report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ and propose a unified…
Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
New work from @stephentang23 et al. that describes a fascinating set of reverse transcriptases involved in antiviral immunity. They synthesize tandem-repeat cDNAs that resemble telomeres, revealing an unexpected bacterial evolutionary origin of telomerase. Check out the thread!
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. doi.org/10.1101/2025.1…
Fascinating study from the Mao & Jiang lab: four amino acid residues unique to naked mole-rat cGAS, but absent in humans, are critical for efficient DNA repair, delaying aging and expanding life span. science.org/doi/epdf/10.11…
As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science science.org/doi/10.1126/sc…
One of my favorite technologies, developed in recent years, is two-photon holographic optogenetics. It is a way to both stimulate and record activity from thousands of individual neurons in real-time; akin to playing the brain like a piano. Here is how it works: In classical…
How does hunger spur us to consume? @Columbia scientists have found a brain area that drives mice to consume sweets, fats, salt & food. This finding may inform novel treatments for both overeating and undereating. See @CellCellPress #neuroscience zuckermaninstitute.columbia.edu/brain-dial-con…
CSF total tau as a proxy of synaptic degeneration: nature.com/articles/s4146…
Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators. nature.com/articles/s4158…
We’re excited to announce our new paper on Time-deterministic cryo-optical microscopy! This technique rapidly freezes living cells during imaging, adding temporal info to cryo-fixed samples for deeper analysis. Huge thanks to our amazing collaborators. nature.com/articles/s4137…
SLC45A4 is a pain gene encoding a neuronal polyamine transporter | Nature nature.com/articles/s4158…
New "Mindscapes" exhibit @ZuckermanBrain featuring #cryoEM structures of #TMEM106B #amyloid fibrils (doi.org/10.1016/j.cell…) & the ligand-bound human sweet receptor (doi.org/10.1016/j.cell…) from the Fitzpatrick (fitzpatrick-lab.org) & Zuker (zukerlab.com) labs.
CryoEM structure of the human uromodulin filaments (PDB code: 9NU3) #scivis #molecularart @dzine_ai @proteinimaging behance.net/gallery/226765…
New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07
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