Molecular Biophysics Unit, IISc
@MBU_IISc
Molecular Biophysics Unit (MBU) is a part of IISc that pursues cutting edge research in the areas of molecular biophysics and structural biology
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The abstract submission is extended till 24th April. Register and attend the exciting symposium!
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: sites.google.com/view/ai-in-bio… Poster abstract deadline: April 18 Registration deadline: April 24
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: sites.google.com/view/ai-in-bio… Poster abstract deadline: April 18 Registration deadline: April 24
The last date for submitting online applications for Research programmes for the Academic Year 2025-26 has been extended till *06 April 2025* iisc.ac.in/admissions/
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif by Debostuti Ghoshdastidar and Manju Bansal at @MBU_IISc hubs.li/Q02YHVL70 @BiophysJ highlight — An official journal of @BiophysicalSoc
Check out the special issue of "Proteins: Structure, Function, and Bioinformatics Vol 93 (1): Jan 2025" commemorating GN Ramachandran Centenary @MBU_IISc. Link: onlinelibrary.wiley.com/toc/10970134/2…
Out in Eur. Phys. J. Spec. Top., rdcu.be/dYTsy. We use our replica exchange with hybrid tempering (REHT) method to extract the Boltzmaan's weighted membrane-bound conformations of peripheral proteins. All work by grad student @mouli_njr, a Physican turned Biophysicist.
Published version of the preprint now available! The link to the preprint thread is below. Congratulations Sanjna @2point0Sam!! Link: journals.physiology.org/doi/abs/10.115…
Preprint from our laboratory with work by Sanjna Kumari @2point0Sam demonstrates ion-channel degeneracy in a large morphologically realistic model population constrained by electrophysiological measurements from our lab in rat hippocampal granule cells (1/2)
Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR | Journal of the American Chemical Society @MBU_IISc #HydroxylExchange #Glycans #NMR @nmr900 pubs.acs.org/doi/10.1021/ja…
We are excited to start the new year by sharing the latest paper from our lab @MBU_IISC, @iiscbangalore in @NAR_Open. Here, we report that the RTEL1 helicase interacts directly and functionally with the replication protein A (RPA). (1/5) @NIRANJANSAARC academic.oup.com/nar/article/do…
academic.oup.com
Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides insights...
Abstract. The regulator of telomere elongation helicase 1 (RTEL1) plays roles in telomere DNA maintenance, DNA repair, and genome stability by dismantling
Our recent work "The alteration of structural network upon transient association between proteins studied using graph theory" is out now in Protein: Structure Function and Bioinformatics @WileyBiomedical doi.org/10.1002/prot.2… @tandon_himani @caps_ncbs @MBU_IISc @iiscbangalore
Our work on the "Comparison of structural networks across homologous proteins" is out in PROTEINS: Structure, Function, and Bioinformatics | Wiley Online Journal @WileyBiomedical onlinelibrary.wiley.com/doi/abs/10.100… @MBU_IISc
#glycotime Out now in GLYCOBIOLOGY! Very chuffed to see this out as it's our first Glycan work !!! doi.org/10.1093/glycob… Thanks to @RamrayB @hurryram @PenmatsaLab for discussions and insights! Also, thanks to @AnneImberty & @GlycobiologyUK for the smooth editorial process.
#glycotime The availability of physiologically unaltered Lili-Mip structure (in vivo crystals solved by @hurryram group) made it a very attractive model system to investigate the role of glycans on protein structure, dynamics, and function using MD sims. tinyurl.com/glycanMD
jbc.org/article/S0021-… Out now in @jbiolchem. Had a wonderful time working with @ShovamayeeMaha and @Sangeethayoga, who did all the heavy lifting !! Would like to acknowledge @India_Alliance, NSM (HPC grant @IndiaDST) @SankhyaSutraLab @DBTIndia @iiscbangalore @MBU_IISc
In our recent work, we provide high-resolution structural insights into the RNA-FUS binding. @Sangeethayoga and I are having a blast collaborating with FUS Zen master @ShovamayeeMaha @RNALab_Maharana :-) (Preprints link) tinyurl.com/RNAFUS-AAMD Salient findings in thread below
We are organizing our annual symposium, "NuBS23," tomorrow from 9 AM onwards at the Faculty Hall, IISc Main Building. Please join us to learn about our latest works and hear from our plenary speakers, @gsahu_iisc and @AshhadSufyan.
Very happy to share our recent study on characterization and comparison of permanent and transient intra-protein inter-domain interactions. doi.org/10.1002/prot.2…
Finally our research on thioamide modification and its implications in membrane permeability and bioavailability of cyclic peptides is out! Congratulations to the entire team! nature.com/articles/s4146… @hiteshvrm @b_khatrii @NishantRaj33828 @SohiniBioPharma @MBU_IISc
Its a pleasure to announce the publication of our latest work on the cryoEM structure of QacA resolved using Indian camelid antibodies in @embojournal . Fantastic effort by @PujaMajumder91 @shah_med @Pragyaahuja_6 and @Athreya_Arunabh.embopress.org/doi/full/10.15…
Excited to announce the publication of our study on the architecture of the ratGAT1 in the cytosol-facing, GABA bound state @NatureSMB. Brilliant effort @SmrutiR60158682 and well supported by @DeepthiJoseph @ArchishmanDakua @AthreyaArunabh nature.com/articles/s4159…
Very happy to share our study uncovering the mechanism of DNA binding by an IDP! The disordered domain of CytR binds DNA through a fully folded minor conformation. @AthiNaganathan @BODHISATWANANDI @MBU_IISc science.org/doi/10.1126/sc…
doi.org/10.1021/acs.jc… Out now in JCTC!! Very proud of @RajeswariAppad1 for this wonderful effort!! And loved the collaboration with @PaulRobustelli @koduruJayakris1 and @BonomiMax Also, thanks to @iiscbangalore, National Supercomputing Mission @IndiaDST @DBTIndia for ₹₹
tinyurl.com/IDP-tSNE A "method" paper from us on demultiplexing heterogeneous conformations of IDPs into structurally similar clusters. @RajeswariAppad1 and I really enjoyed working with @PaulRobustelli @koduruJayakris1 @BonomiMax on this one. Code: github.com/codesrivastava…
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