Molecular Biophysics Unit, IISc
@MBU_IISc
Molecular Biophysics Unit (MBU) is a part of IISc that pursues cutting edge research in the areas of molecular biophysics and structural biology
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API & Biosimilar QC/R&D experts: Hands-on NMR Data Acquisition Workshop. Industry participants only. Strictly 10 seats. Investment: ₹1.5L + GST Apply now! cce.iisc.ac.in/self-support-c… #NMRSpectroscopy #Pharma #biotech #IISc #APIManufacturing #Biosimilars #QC #RND
The abstract submission is extended till 24th April. Register and attend the exciting symposium!
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: sites.google.com/view/ai-in-bio… Poster abstract deadline: April 18 Registration deadline: April 24
We are organizing a 2-day "AI in Biophysics" symposium from 28-29 April. We bring together leading experts to facilitate interdisciplinary and lively discussions. Website: sites.google.com/view/ai-in-bio… Poster abstract deadline: April 18 Registration deadline: April 24
The last date for submitting online applications for Research programmes for the Academic Year 2025-26 has been extended till *06 April 2025* iisc.ac.in/admissions/
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif by Debostuti Ghoshdastidar and Manju Bansal at @MBU_IISc hubs.li/Q02YHVL70 @BiophysJ highlight — An official journal of @BiophysicalSoc
Check out the special issue of "Proteins: Structure, Function, and Bioinformatics Vol 93 (1): Jan 2025" commemorating GN Ramachandran Centenary @MBU_IISc. Link: onlinelibrary.wiley.com/toc/10970134/2…
Out in Eur. Phys. J. Spec. Top., rdcu.be/dYTsy. We use our replica exchange with hybrid tempering (REHT) method to extract the Boltzmaan's weighted membrane-bound conformations of peripheral proteins. All work by grad student @mouli_njr, a Physican turned Biophysicist.
Published version of the preprint now available! The link to the preprint thread is below. Congratulations Sanjna @2point0Sam!! Link: journals.physiology.org/doi/abs/10.115…
Preprint from our laboratory with work by Sanjna Kumari @2point0Sam demonstrates ion-channel degeneracy in a large morphologically realistic model population constrained by electrophysiological measurements from our lab in rat hippocampal granule cells (1/2)
Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR | Journal of the American Chemical Society @MBU_IISc #HydroxylExchange #Glycans #NMR @nmr900 pubs.acs.org/doi/10.1021/ja…
We are excited to start the new year by sharing the latest paper from our lab @MBU_IISC, @iiscbangalore in @NAR_Open. Here, we report that the RTEL1 helicase interacts directly and functionally with the replication protein A (RPA). (1/5) @NIRANJANSAARC academic.oup.com/nar/article/do…
Our recent work "The alteration of structural network upon transient association between proteins studied using graph theory" is out now in Protein: Structure Function and Bioinformatics @WileyBiomedical doi.org/10.1002/prot.2… @tandon_himani @caps_ncbs @MBU_IISc @iiscbangalore
Our work on the "Comparison of structural networks across homologous proteins" is out in PROTEINS: Structure, Function, and Bioinformatics | Wiley Online Journal @WileyBiomedical onlinelibrary.wiley.com/doi/abs/10.100… @MBU_IISc
#glycotime Out now in GLYCOBIOLOGY! Very chuffed to see this out as it's our first Glycan work !!! doi.org/10.1093/glycob… Thanks to @RamrayB @hurryram @PenmatsaLab for discussions and insights! Also, thanks to @AnneImberty & @GlycobiologyUK for the smooth editorial process.
#glycotime The availability of physiologically unaltered Lili-Mip structure (in vivo crystals solved by @hurryram group) made it a very attractive model system to investigate the role of glycans on protein structure, dynamics, and function using MD sims. tinyurl.com/glycanMD
jbc.org/article/S0021-… Out now in @jbiolchem. Had a wonderful time working with @ShovamayeeMaha and @Sangeethayoga, who did all the heavy lifting !! Would like to acknowledge @India_Alliance, NSM (HPC grant @IndiaDST) @SankhyaSutraLab @DBTIndia @iiscbangalore @MBU_IISc
In our recent work, we provide high-resolution structural insights into the RNA-FUS binding. @Sangeethayoga and I are having a blast collaborating with FUS Zen master @ShovamayeeMaha @RNALab_Maharana :-) (Preprints link) tinyurl.com/RNAFUS-AAMD Salient findings in thread below
We are organizing our annual symposium, "NuBS23," tomorrow from 9 AM onwards at the Faculty Hall, IISc Main Building. Please join us to learn about our latest works and hear from our plenary speakers, @gsahu_iisc and @AshhadSufyan.
Very happy to share our recent study on characterization and comparison of permanent and transient intra-protein inter-domain interactions. doi.org/10.1002/prot.2…
Finally our research on thioamide modification and its implications in membrane permeability and bioavailability of cyclic peptides is out! Congratulations to the entire team! nature.com/articles/s4146… @hiteshvrm @b_khatrii @NishantRaj33828 @SohiniBioPharma @MBU_IISc
Its a pleasure to announce the publication of our latest work on the cryoEM structure of QacA resolved using Indian camelid antibodies in @embojournal . Fantastic effort by @PujaMajumder91 @shah_med @Pragyaahuja_6 and @Athreya_Arunabh.embopress.org/doi/full/10.15…
Excited to announce the publication of our study on the architecture of the ratGAT1 in the cytosol-facing, GABA bound state @NatureSMB. Brilliant effort @SmrutiR60158682 and well supported by @DeepthiJoseph @ArchishmanDakua @AthreyaArunabh nature.com/articles/s4159…
Very happy to share our study uncovering the mechanism of DNA binding by an IDP! The disordered domain of CytR binds DNA through a fully folded minor conformation. @AthiNaganathan @BODHISATWANANDI @MBU_IISc science.org/doi/10.1126/sc…
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