Maday Lab
@MadayLab
The Maday lab investigates the mechanisms, regulation, and functions of autophagy in neuronal homeostasis and neurodegeneration @Penn @PennNGG @CAMBUpenn
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Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains: Molecular Cell cell.com/molecular-cell…
Fluorescence lifetime-based biosensor for monitoring compartmentalized autophagy dynamics in the intact mammalian brain: biorxiv.org/content/10.648…
Our new collaborative review is out! Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders tandfonline.com/doi/full/10.10…
Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders: tandfonline.com/doi/full/10.10…
Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains: biorxiv.org/content/10.110…
Congratulations Eran and team!!!! @LabPerlson
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models, exciting work form @LabPerlson! nature.com/articles/s4159…
Thank you @RealEricDane for joining us in this critical movement!
We're launching our Push for Progress campaign to accelerate ALS research, expand treatment access, & secure $1BN in federal funding over 3 years. ALS is at a tipping point CLOSE to new treatments, but thousands will lose access unless we TAKE ACTION @ iamals.org/progress
New preprint from the lab. Amazing work from Ha Nguyen, PhD student in our lab. Thanks to collaborators! See thread 👇
Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.110…. We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.
Our paper!!!!🥰
Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses dlvr.it/TLyKnC
Congratulations Swetha!! This is fantastic news!!! 🎉🎉🎉
Delighted to share that I have been promoted to Associate Professor with tenure at UIC! Thank you to all lab members, current and past, mentors, collaborators, firends and family🎉
New lab preprint! Head over to 🦋 for the full thread!! biorxiv.org/content/10.110…
“Why stop now, when we haven’t yet realized immunotherapy’s full potential?” In a new @NatRevDrugDisc interview, @mellmani, PhD, President of Research at PICI, shares what’s next in #CancerImmunotherapy—from curative cell therapies to smarter T cells. Read more:…
New online! DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation bit.ly/3FXBqxP
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