Mark Borris Aldonza (@precursorcell.bsky.social🦋)
@PrecursorCell
@eLife ambassador. Researcher/PhD @KAISTPR × @SeoulNatlUni. Passionately working on cancer👾 and evolution🪸🦈. Fanconi anemia survivor🟥.
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Hot off the press 🔥! My co-first authored paper is out @ScienceAdvances!! A tour de force collab work with @new__hong @MethylAReum. We unlock for the first time the dog epigenome! 🐕 🧬 @SeoulNatlUni @je_yoel #ENCODE #epigenome #epigenetics #ScienceAdvancesResearch
Exciting news! Our lab’s latest paper in @ScienceAdvances on mapping the dog epigenome is out 🐶🧬! Close collaboration with my co-first authors @PrecursorCell + @MethylAReum! 🧵 👇(1/17) #ScienceResearch #ScienceAdvancesResearch #Epigenome science.org/doi/10.1126/sc…
A pre-trained large generative model for translating single-cell transcriptomes to proteomes nature.com/articles/s4155… 🧬🖥️🧪 github.com/TencentAILabHe…
Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests. We describe a critical concept that we call *specificity*. Led by Jeff Spence and Hakhamanesh Mostafavi:
How do GWAS and rare variant burden tests rank gene signals? In new work @Nature with Jeff Spence, @jkpritch, and our wonderful coauthors we find the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 nature.com/articles/s4158…
A study out today in @NatureGenet from Core Investigator @LukeGilbertSF, @li_haolong & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
New online! Genomics of drug target prioritization for complex diseases bit.ly/3JKy9DU
By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data. @gjhuizing @JulesSamaran @gabrielpeyre @cantinilab nature.com/articles/s4159…
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)
New in @Nature, @LabNowakowski & team use barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. nature.com/articles/s4158… #studyBRAIN
A multi-tissue atlas of genetic regulatory effects in sheep biorxiv.org/content/10.110… #biorxiv_genomic
>7000 miles away from NYC but we can feel the positive swarm of hopes and dreams. Here's the Autumn-Winter scene at KAIST in Daejeon🇰🇷 to let you in with the vibe
Hot off the press @NeuroCellPress "From variants to mechanisms: Neurogenomics in the post-GWAS era" Genetic architect -> biological mech for ASD/SCZ/AD Major effort led by MSTP student Michael Margolis + great collab w/ @MichaelZiller5 & @WrayNaomi bit.ly/4oSunr1
From code → complex structures 🧬 Meet OpenFold3 NIM: A production-ready model for predicting proteins, nucleic acids & ligands at lightning speed. Dive in 👉 nvda.ws/3JxauqA
Lymphoid gene expression supports neuroprotective microglia function @nature nature.com/articles/s4158…
Nature research paper: Origins of chromosome instability unveiled by coupled imaging and genomics go.nature.com/4oExnHs
(1/10) How do diverse leukemia mutations converge on the same molecular program? In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧
We’re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!👉biorxiv.org/content/10.110… In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field…
Wait.... this is really big.... those LoF gene constraint selection used in many screening pipelines...
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬 A big step for precision medicine! nature.com/articles/s4146…
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬 A big step for precision medicine! nature.com/articles/s4146…
KATMAP infers splicing factor activity and regulatory targets from knockdown data go.nature.com/47ycrMJ
🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD + @das_tandrila 🧵1/ nature.com/articles/s4158…
Together with @mito_oncogene, today we report in Nature Genetics a peculiar + exciting discovery: positive selection of mutations to mitochondrial ribosomal RNA in cancer. Led by Sonia Boscenco, Jacqueline Tait-Mulder, and Minsoo Kim nature.com/articles/s4158…
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