Scleroderma Lab Leeds
@SclerodermaLab
The Scleroderma Research Programme is a patient oriented multidisciplinary research team comprising basic, translational and clinical research on Scleroderma
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#ResearchHighlight | Targeting pDCs in SSc #SystemicSclerosis #scleroderma #rheumatology Read the original research from @SclerodermaLab @ARD_BMJ here bit.ly/3kWr0Q1 Read our #news story here go.nature.com/2OCLtxq
I am delighted to share the approval of Actemra for SSc related ILD. The FDA was pragmatic and approved the medication, based on large clinically meaningful effect on lung function. #scleroderma #hope @UMIntMed @genetec gene.com/media/press-re…
Check out our latest paper in @RheumJnl where we show the intracellular chloride channel 4 (CLIC4) plays a role in SSc fibroblast activation. This is one of the first examples of an ion channel playing an important role in the disease. academic.oup.com/rheumatology/a…
New work from the group just published in @ArthritisRes. We have shown HOTAIR regulates the expression of the sonic hedgehog transcription factor GLI2 in scleroderma fibroblasts. A great collaboration with the @thehedgehoglab. arthritis-research.biomedcentral.com/articles/10.11…
Our latest collaboration with Mark Ditzel, Bob Hill and Katherine Staines is live! Ubiquitin-protein ligase Ubr5 cooperates with Hedgehog signalling to promote skeletal tissue homeostasis biorxiv.org/content/10.110…
Earlier today Dr Del Galdo answered questions from concerned scleroderma patients on Covid19 in context to scleroderma facebook.com/WeAreSRUK/vide…
LTHT Rheumatology COVID immunosuppressants 31 3 20 youtu.be/ZGROdmpcyj8 via @LTHT_People @CAHTriTeam1 @LeedsBRC @WeAreSRUK @SclerodermaLab
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LTHT Rheumatology COVID immunosuppressants 31 3 20
REVIEW: Randomised controlled trials in #SystemicSclerosis: patient selection and endpoints for next generation trials thelancet.com/journals/lanrh… #LancetRheumatology #RareDiseaseDay #SSc
Raise your hands to help these hands on Friday the 28th February - all proceeds go to Scleroderma and Raynaud's research @leedsmedhealth
Very happy that this work is now out in annals of rheumatic diseases. We have identified that the long non-coding RNA HOTAIR plays a important role in scleroderma fibroblast activation ard.bmj.com/content/early/…
February is Raynaud’s Awareness Month, which is why we're asking people to take our quick and simple online test to give those affected by the condition the chance to better understand, and manage, their symptoms. 👏 Take 👏 The 👏 Test 👏 sruk.co.uk/testme #KnowRaynauds
New pre print from the group in collaboration with @VHIT_Mckimmie
Targeting BDCA2 suppresses Plasmacytoid dendritic cell dependent interferon response and tissue fibrosis biorxiv.org/cgi/content/sh… #bioRxiv
In our paper out today in @ScienceTM by @BrevenStyden et al, we show that stimulating the body’s immune defence at the mosquito bite is highly effective at suppressing infection with many distinct viruses. Works for alpha-, flavi-, and bunya-viruses. 1/n stm.sciencemag.org/content/12/527…
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